Lodoxamide

Children. Pregnancy and lactation.

Significant: Eye discomfort, transient stinging or burning; blurred vision or visual disturbances.
Ear and labyrinth disorders: Eye pruritus, pain, oedema, discharge or irritation; increased lacrimation, ocular hyperaemia, asthenopia, corneal deposits, conjunctival oedema, abnormal sensation in eye, foreign body sensation in eyes, eyelid exfoliation.
Gastrointestinal disorders: Nausea.
General disorders and administration site conditions: Feeling hot or temporary warm sensation.
Nervous system disorders: Headache, dizziness.
Skin and subcutaneous tissue disorders: Skin rash.

Ophth: B

This drug may cause temporary blurred vision or other visual disturbances, if affected, do not drive or operate machinery. Remove contact lenses prior to administration and reinsert after at least 15 minutes.

Monitor for eye discomfort, transient stinging or burning.

Description:
Mechanism of Action: Lodoxamide is a mast cell stabiliser that blocks type 1, IgE-mediated (immediate) hypersensitivity reactions. It also inhibits the release and activation of mast cell inflammatory mediators such as histamine and leukotrienes (e.g. slow reacting substance of anaphylaxis) and prevents eosinophil chemotaxis.
Pharmacokinetics:
Excretion: Via urine. Elimination half-life: 8.5 hours.

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 44564, Lodoxamide. https://pubchem.ncbi.nlm.nih.gov/compound/Lodoxamide. Accessed Apr. 28, 2024.

Store between 20-25°C. Do not freeze.

Thuốc giảm sung huyết, gây tê, kháng viêm trong Nhãn khoa

S01GX05 - lodoxamide ; Belongs to the class of other ophthalmologic antiallergics.

Alomide 0.1% w/v Eye Drops, Solution (Novartis Pharmaceuticals UK Limited). MHRA. https://products.mhra.gov.uk. Accessed 02/04/2024.

Alomide Solution/Drops (Novartis Pharmaceuticals Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/04/2024.

Anon. Lodoxamide. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 02/04/2024.

Buckingham R (ed). Lodoxamide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/04/2024.

Joint Formulary Committee. Lodoxamide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/04/2024.

Lodoxamide. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/04/2024.

Novartis New Zealand Limited. Lodoxamide Trometamol 0.1% Eye Drops data sheet 25 May 2023. Medsafe. http://www.medsafe.govt.nz. Accessed 02/04/2024.

Paediatric Formulary Committee. Lodoxamide. BNF for Children [online]. London. BMJ Group, Pharmaceutical Press, and RCPCH Publications. https://www.medicinescomplete.com. Accessed 02/04/2024.