|
Chỉ định và Liều dùng
Ophthalmic
Herpes simplex keratitis Adult: As 0.1% soln: Instill 1 drop in the affected eye(s) every hr. Taper to every 2 hr or 4 times daily. Continue treatment for at least 7 days. Topical/Cutaneous Cutaneous herpes simplex and herpes zoster Adult: As 5% preparation: Paint onto the lesions 4 times daily for 4 days.
|
|
Chống chỉ định
Hypersensitivity.
|
|
Thận trọng
Deep ulceration of the stromal layers of the cornea. Avoid prolonged use. Pregnancy and lactation.
|
|
Tác dụng không mong muốn
Ophthalmic: Irritation; inflammation of the eye or eyelids; pain; photophobia; pruritus; conjunctivitis; oedema. Rarely, lachrymal duct occlusion and hypersensitivity reactions. Corneal damage (prolonged use). Topical: Irritation; stinging; hypersensitivity reactions; corneal punctate defects or skin maceration (when applied excessively).
|
|
Ophth: Z (Embryo-foetal malformations were observed in animal studies. Not recommended.)
|
|
Tương tác
Corticosteroids may accelerate spread of viral infection.
|
|
Tác dụng
Description:
Mechanism of Action: Idoxuridine, a pyrimidine nucleoside structurally related to thymidine, inhibits viral replication by substituting itself for thymidine in viral DNA. It is active against herpes simplex and varicella zoster viruses, and has also been shown to inhibit vaccinia virus, cytomegalovirus and adenovirus. Pharmacokinetics: Absorption: Poor penetration into the skin and cornea. Metabolism: Metabolised rapidly in the body to iodouracil, uracil and iodide. Excretion: Metabolites are excreted in the urine. |
|
Bảo quản
Ophthalmic:
Store between 36-80°F. |
|
Phân loại MIMS
|
Đăng ký miễn phí để được tiếp tục đọc
Tiếp tục với Google
Đăng ký với email
Đã là thành viên?
Đăng nhập
Đăng xuất
