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Indications and Dosage
Oral
Osteoarthritis Adult: As glucosamine sulfate conventional tab, cap, or powder for oral solution: 1,500 mg daily as a single dose or in divided doses of up to 3 times daily. As glucosamine hydrochloride effervescent tab or cap: 1,250 mg once daily. Dosage and treatment recommendations may vary among countries and between individual products (refer to specific product guidelines).
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What are the brands available for Glucosamine in Vietnam?
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Other Known Brands
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Administration
Glucosamine Should be taken with food.
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Reconstitution
Effervescent tab: Dissolve tab in at least 100 mL of water. Powder for oral solution: Dissolve the contents of the sachet in at least 250 mL of water.
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Contraindications
Hypersensitivity to glucosamine and shellfish.
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Special Precautions
Patient with known risk factors for CV disease, asthma, diabetes mellitus or impaired glucose tolerance. Not intended for the treatment of acute painful symptoms. Renal and hepatic impairment. Pregnancy and lactation.
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Adverse Reactions
Significant: Hypercholesterolaemia, exacerbation of asthma.
Gastrointestinal disorders: Nausea, diarrhoea, abdominal pain, dyspepsia, constipation, flatulence. General disorders and administration site conditions: Tiredness. Nervous system disorders: Headache, somnolence. Skin and subcutaneous tissue disorders: Rash, itching. Vascular disorders: Flushing. |
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Monitoring Parameters
Monitor blood lipid levels (particularly in patients with risk factors for CV disease); blood glucose levels before treatment and periodically thereafter (in patients with impaired glucose tolerance).
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Overdosage
Symptoms: Headache, arthralgia, nausea, vomiting, disorientation, dizziness, diarrhoea, constipation. Management: Supportive treatment.
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Drug Interactions
May enhance the effect of coumarin anticoagulants (e.g. warfarin). May increase the absorption and serum concentrations of tetracyclines.
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Action
Description:
Mechanism of Action: Glucosamine, a natural substance, is a component of mucopolysaccharides, mucoproteins, and chitin. Its mechanism of action is unknown; however, it has been noted that it stimulates the synthesis of glycosaminoglycans, which form cartilage tissue in the body. Pharmacokinetics: Distribution: Volume of distribution: Approx 5 L. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 439213, D-Glucosamine. https://pubchem.ncbi.nlm.nih.gov/compound/D-Glucosamine. Accessed June 25, 2025. |
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Storage
Store below 30°C.
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ATC Classification
M01AX05 - glucosamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
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References
Arthriex 1,500 mg Film-coated Tablets (TSI Health Sciences [Europe] Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 23/06/2025. Brayfield A, Cadart C (eds). Glucosamine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/06/2025. Dolenio 500 mg Film-coated Tablets (Blue Bio Pharmaceuticals Ltd.). MHRA. https://products.mhra.gov.uk. Accessed 05/06/2025. Dyna-RH Capsule (Dynapharm [M] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 05/06/2025. Flexijoint 1,500 mg Powder (Winwa Medical Sdn. Bhd.). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 05/06/2025. Glucosamine 1,250 mg Effervescent Tablets (Medley Pharma Limited). MHRA. https://products.mhra.gov.uk. Accessed 05/06/2025. Glucosamine Sulphate 1,500 mg Powder for Oral Solution (Crescent Pharma Limited). MHRA. https://products.mhra.gov.uk. Accessed 05/06/2025. Glucosamine. UpToDate Lexidrug, Natural Products Database Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/06/2025. Joint Formulary Committee. Glucosamine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/06/2025. Viartril-S Capsules and Sachets (Viatris Pharmaceuticals, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 05/06/2025. Yointy 625 mg Hard Capsules (Laboratorio Reig Jofre S.A.). MHRA. https://products.mhra.gov.uk. Accessed 05/06/2025.
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