Gliquidone

Should be taken with food.

Type 1 diabetes mellitus; ketoacidosis; severe infection; trauma; other severe conditions where gliquidone is unlikely to control hyperglycaemia; pregnancy; lactation; porphyria; hypersensitivity; diabetic coma and pre-coma; prediabetic states; severe hepatic or renal impairment.

Elderly, debilitated or malnourished patients; adrenal or pituitary insufficiency. Monitor blood glucose concentrations carefully.

GI disturbances; metallic taste; skin rashes, pruritus, photosensitivity; facial flushing; hypoglycaemia; syndrome of inappropriate secretion of antidiuretic hormone; cholestatic jaundice; Stevens-Johnson syndrome; exfoliative dermatitis; erythema nodosum; increased appetite; wt gain; blood disorders.

Increased hypoglycaemic effect by ACE inhibitors, alcohol, allopurinol, some analgesics, azole antifungals, cimetidine, clofibrate and related compounds, coumarin anticoagulants, halofenate, heparin, octreotide, ranitidine, sulfinpyrazone, sulfonamides, tricyclic antidepressants, thyroid hormones, MAOIs, chloramphenicol, tetracyclines. β-blockers increase hypoglycaemia and may mask warning signs. Diminished hypoglycaemic effect by adrenaline, aminoglutethimide, diazoxide, rifamycins, chlorpromazine, corticosteroids, oral contraceptives, hormones, thiazide diuretics.

Altered liver enzyme values.

Description:
Mechanism of Action: Gliquidone stimulates the production of organic insulin and normalizes the altered metabolic situation when diet alone cannot regulate this satisfactorily.

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