Fluspirilene

Comatose states, CNS depression, phaeochromocytoma.

Hepatic impairment, renal impairment, CV disease, Parkinson's disease, epilepsy, depression, myasthenia gravis, prostatic hypertrophy, severe resp disease, blood dyscrasias and history of jaundice. Elderly. Pregnancy and lactation. Antipsychotics may precipitate coma due to their hepatotoxicity. Photosensitisation may occur in higher doses. May impair ability to drive and operate machines.

Parkinsonian symptoms, dystonia, akathisia, tardive dyskinesia. Interference with temp regulation. Neuroleptic malignant syndrome. CNS effects, GI disturbances, nasal congestion, antimuscarinic symptoms, CV symptoms, ECG changes, endocrine effects, blood dyscrasias, photosensitisation, contact sensitisation and rashes, jaundice, corneal and lens opacities, purplish pigmentation of the skin, cornea, conjunctiva and retina.

ACE inhibitors, α-blockers, amantadine, general anaesthetics, angiotensin-II receptor antagonists, antiarrhythmics, tricyclic antidepressants, anxiolytics and hypnotics, apomorphine, artemether with lumefantrine, barbiturates, bromocriptine, cabergoline, calcium-channel blockers, carbamazepine, cimetidine, ethosuximide, levodopa, lisuride, memantine, methyldopa, metoclopramide, opioid analgesics, oxcarbazepine, pergolide, phenytoin, pramipexole, primidone, ritonavir, ropinirole, sibutramine, sympathomimetics, terfenadine, tetrabenazine, tramadol and valproate. Alcohol.

Description:
Mechanism of Action: Fluspirilene is a diphenylbutylpiperidine antipsychotic and has general properties similar to those of the phenothiazine, chlorpromazine. It is used in the treament of schizophrenia.

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