Otic/Aural Inflammation of the external ear with suspected secondary infection
Adult: As soln containing flumetasone pivalate 0.02% and clioquinol 1%: Instill 2 or 3 drops bid directly into the auditory canal of the affected ear for 7-10 days. Patient should be seated or lying down w/ the treated ear turned upwards during application. Maintain this position for at least 1-2 min after application. Child: ≥2 yr Same as adult dose.
Các sản phẩm có chứa hoạt chất Flumetasone + Clioquinol tại Việt Nam?
Lorinden
Chống chỉ định
Perforation of the tympanic membrane, disorders associated w/ therapy-resistant secondary infection, iodine sensitivity, primary bacterial, viral, or fungal infection of the outer ear. Childn <2 yr.
Thận trọng
Patient w/ thyroid abnormalities. Childn. Pregnancy and lactation.
Tác dụng không mong muốn
Endocrine: Adrenal suppression (prolonged use). Ophthalmologic: Increased risk of cataract. Dermatologic: Skin atrophy, telangiectasia, purpura, striae, dermatitis, skin depigmentation, hair colour changes, hypertrichosis, application site burning or irritation, rash, pruritus, impaired healing. Immunologic:Hypersensitivity, manifestations of bacterial, viral, or fungal infection.
Thông tin tư vấn bệnh nhân
This drug may cause discolouration of skin, hair, and cloth. Avoid application to the eye.
Ảnh hưởng đến kết quả xét nghiệm
May interfere w/ thyroid function tests (e.g. PBI, radioactive iodine and butanol extractable iodine). May cause false-positive ferric chloride test for phenylketonuria.
Tác dụng
Description: Mechanism of Action: Flumetasone pivalate is a moderately potent glucocorticoid, usually used for local application. It has an anti-inflammatory, anti-allergic, vasoconstrictive and anti-proliferative effect. Clioquinol, is a halogenated hydroxyquinoline derivative which exerts its bacteriostatic action by chelating bacterial surface and trace metals needed for bacterial growth. Pharmacokinetics: Absorption: Clioquinol: Approx 1.5-4% is absorbed. Excretion: Clioquinol: Via urine, mainly as glucuronide, and as sulfate (small amounts).
Đặc tính
Flumetasone Source: National Center for Biotechnology Information. PubChem Database. Flumethasone, CID=16490, https://pubchem.ncbi.nlm.nih.gov/compound/Flumethasone (accessed on Jan. 21, 2020)
Clioquinol Source: National Center for Biotechnology Information. PubChem Database. Clioquinol, CID=2788, https://pubchem.ncbi.nlm.nih.gov/compound/Clioquinol (accessed on Jan. 21, 2020)
Anon. Clioquinol and Flumethasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/03/2017 .Joint Formulary Committee. Clioquinol with Flumetasone Pivalate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/03/2017 .
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