Fludiazepam

Preexisting CNS depression or coma, resp depression, acute pulmonary insufficiency or sleep apnoea; severe hepatic impairment; not indicated for chronic psychosis, phobic or obsessional states; may precipitate suicide or aggressive behavior, not used alone to treat depression or anxiety associated with depression; glaucoma.

Chronic pulmonary insufficiency; elderly or debilitated patients; muscle weakness, impaired liver or kidney function; drowsiness may affect skilled tasks; monitor cardio-respiratory function when used for deep sedation; patients with personality disorders or organic brain changes; pregnancy and lactation; history of alcohol or drug addiction due to risk of dependence. resp depression and hypotension with parenteral admininistration, therefore this route should only be used when facilities for reversing resp depression are available.

Drowsiness, sedation, muscle weakness and ataxia; less frequently vertigo, headache, confusion, depression, slurred speech, changes in libido, tremor, visual disturbances, urinary retention, GI disturbances, changes in salivation and amnesia; rarely, jaundice, blood disorders and hypersensitivity reactions; pain and thrombophloebitis; raised liver enzyme values; paradoxical excitation.

Enhanced sedation or resp and CV depression with drugs that have CNS depressant properties eg, antidepressants, antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, opioid analgesics and cisapride. Alcohol enhances sedation or resp and CV depression effects.
Potentially Fatal: Drugs which alter the hepatic microsomal enzymes.

Description:
Mechanism of Action: Fludiazepam is a short-acting benzodiazepine with general properties similar to diazepam. It is used in the short-term treatment of anxiety disorders.

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