Ferric derisomaltose

Adult: In cases when oral Fe therapy is ineffective or cannot be used, and when there is a need to deliver Fe rapidly: As solution for inj or infusion containing 100 mg Fe as ferric derisomaltose/mL: Dosage may be determined using a simplified table based on patient's Hb level and body weight (refer to local product information for the detailed dosing table). Alternatively, the dosage may be calculated using the Ganzoni formula, iron need (mg) = body weight (kg) x (target Hb [g/dL] - actual Hb [g/dL]) x 2.4 + Fe stores (mg). The Fe stores are ≥500 mg in patients with >35 kg body weight; however, some guidelines suggest using 10-15 mg Fe/kg body weight. Doses via bolus inj: Administer up to 500 mg 1-3 times weekly at a Max rate of 250 mg/minute. A single IV bolus inj must not exceed 500 mg Fe. Doses via infusion: Given as a single infusion (Max of 20 mg/kg) or as weekly infusions until the cumulative Fe dose is administered. If the cumulative Fe dose is >20 mg/kg, administer in 2 divided doses with at least 1 week interval. IV infusion doses of ≤1,000 mg are given over at least 15 minutes and doses >1,000 mg are given over at least 30 minutes. All doses are expressed in mg of elemental Fe. Re-assess Hb levels at least 4 weeks after the last administration, then recalculate the Fe need if the patient requires further Fe repletion. Dosage recommendations may vary between countries and individual products (refer to specific product or local official guidelines).