Faricimab

Thông tin thuốc gốc
Chỉ định và Liều dùng
Intravitreal
Neovascular (wet) age-related macular degeneration
Adult: Initially, 6 mg (0.05 mL) once every 4 weeks (approx every 28 days) for the 1st 4 doses. Assess disease activity 20 and/or 24 weeks after treatment initiation and individualise dosing frequency based on anatomic and/or visual outcomes. In patients without disease activity: 6 mg once every 16 weeks. In patients with disease activity: 6 mg once every 8 or 12 weeks. Discontinue treatment if visual and/or anatomic outcomes indicate that the patient is not benefitting from continued treatment.

Intravitreal
Diabetic macular oedema
Adult: 6 mg (0.05 mL) once every 4 weeks (approx every 28 days) for the 1st 4 doses. Subsequent doses may be individualised using a treat-and-extend approach based on anatomic and/or visual outcomes. The treatment interval may be extended from every 4 to every 16 weeks, with extensions in increments of up to 4 weeks or reductions of up to 8-week intervals based on anatomic and/or visual outcomes. Alternatively, 6 mg (0.05 mL) once every 4 weeks for the 1st 6 doses, followed by 6 mg once every 8 weeks over the next 28 weeks. Discontinue treatment if visual and/or anatomic outcomes indicate that the patient is not benefitting from continued treatment.
Chống chỉ định
Ocular or periocular infections, active intraocular inflammation, IOP ≥30 mmHg.
Thận trọng
Patient with poorly controlled glaucoma, risk factors for retinal pigment epithelial tears, high-risk proliferative diabetic retinopathy, active systemic infections. Diabetic patients with uncontrolled hypertension. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Endophthalmitis, intraocular inflammation, rhegmatogenous retinal detachment, retinal tear, transient increases in IOP, arterial thromboembolic events, including stroke and MI.
Eye disorders: Cataract, conjunctival or vitreous haemorrhage, vitreous floaters, retinal pigment epithelial tear, increased lacrimation, uveitis, vitritis, increased lacrimation, eye pain, irritation or discomfort.
Intravitreal: Z (Avoid unless benefits outweigh risks.)
Thông tin tư vấn bệnh nhân
This drug may cause temporary visual disturbances, if affected, do not drive or operate machinery. Women of childbearing potential must use proven birth control methods during therapy and for at least 3 months after stopping the treatment.
Chỉ số theo dõi
Monitor IOP via tonometry and perfusion of the optic nerve head immediately following administration. Monitor for symptoms of endophthalmitis and retinal detachment (e.g. eye redness or pain, photophobia, blurred vision, other vision changes).
Tác dụng
Description:
Mechanism of Action: Faricimab, a recombinant humanised bispecific immunoglobulin G1 (IgG1) antibody, acts by dual inhibition of vascular endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2). Inhibition of VEGF-A and Ang-2 leads to a reduction of vascular permeability and inflammation, inactivation of pathological angiogenesis and restoration of vascular stability.
Synonym: faricimab-svoa.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: Approx 2 days.
Metabolism: Expected to be catabolised in lysosomes to small peptides and amino acids.
Excretion: Estimated mean ocular and apparent systemic half-life: 7.5 days.
Bảo quản
Store between 2-8°C. Do not freeze. Protect from light. May be stored between 20-25°C for up to 24 hours prior to use.
Phân loại MIMS
Các thuốc nhãn khoa khác
Phân loại ATC
S01LA09 - faricimab ; Belongs to the class antineovasculatisation agents. Used in the management of neovascular macular degeneration.
Tài liệu tham khảo
Anon. Faricimab. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 06/10/2022.

Anon. Faricimab. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/10/2022.

Joint Formulary Committee. Faricimab. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/10/2022.

Vabysmo 120 mg/mL (6 mg/0.05 mL) Solution for Injection (Roche Thailand Ltd., Bangkok). MIMS Thailand. http://www.mims.com/thailand. Accessed 06/10/2022.

Vabysmo 120 mg/mL Solution for Injection (Roche Products Limited). MHRA. https://products.mhra.gov.uk. Accessed 06/10/2022.

Vabysmo Injection, Solution (Genentech, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 06/10/2022.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Faricimab từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2026 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com