Butoconazole

Hypersensitivity.

Consider HIV infection in sexually-active women who have difficulty eradicating recurrent vaginal yeast infections. Pregnancy and lactation.

Gastrointestinal disorders: Abdominal pain or cramps.
Reproductive system and breast disorders: Vulvovaginal burning sensation, pruritus, swelling, and soreness; pelvic pain.

Vag: C

May weaken latex or rubber contraceptive devices (e.g. condoms and diaphragms) which may lead to contraceptive failure; use of these products within 72 hours of therapy is not recommended. Abstain from sexual intercourse and avoid using douches or spermicide during treatment. Avoid contact with the eyes.

Perform appropriate microbiological studies to confirm diagnosis. If clinical symptoms persist, repeat tests to rule out pathogens or other conditions that may predispose to recurrent vaginal fungal infections.

Description:
Mechanism of Action: Butoconazole is an imidazole-derived azole antifungal agent. The exact mechanism of action is unknown; however, it is presumed to inhibit ergosterol biosynthesis by interfering with 14-α demethylase, an enzyme essential for converting lanosterol to ergosterol. This inhibition damages the fungal cell membrane, thereby increasing the permeability of susceptible fungi and causing nutrient leakage.
Pharmacokinetics:
Absorption: Slowly absorbed following intravaginal administration. Time to peak plasma concentration: 12-24 hours.
Excretion: Via urine (2.7%); faeces (2.8%).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 47472, Butoconazole. https://pubchem.ncbi.nlm.nih.gov/compound/Butoconazole. Accessed Sept. 24, 2024.

Store between 15-30°C. Avoid temperatures >30°C.

Thuốc tác dụng lên âm đạo

G01AF15 - butoconazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.

Anon. Butoconazole. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 02/09/2024.

Brayfield A, Cadart C (eds). Butoconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/09/2024.

Butoconazole. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 02/09/2024.

Butoconazole. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/09/2024.

Gynazole 1 Cream (Padagis Israel Pharmaceuticals Ltd). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/09/2024.