Albendazole

Oral
Echinococcosis

Oral
Neurocysticercosis

Oral
Ascariasis, Enterobiasis, Hookworm infections, Trichuriasis

Oral
Strongyloidiasis

Oral
Capillariasis

Oral
Trichostrongyliasis

Albendazole Should be taken with food. Take w/ a high-fat meal to increase oral bioavailability. Tab may be crushed/chewed. Administration on an empty stomach may be appropriate for intraluminal infections.

Hypersensitivity. Pregnancy.

Patient with cysticercosis retinal lesions. May worsen symptoms of neurocysticercosis by inducing an inflammatory response. Hepatic impairment. Children. Lactation.

Significant: Bone marrow suppression, aplastic anaemia, agranulocytosis; mild to moderate elevation of liver enzymes, hepatitis, acute liver failure.
Blood and lymphatic system disorders: Leucopenia, neutropenia.
Gastrointestinal disorders: Nausea, vomiting, abdominal pain, diarrhoea.
General disorders and administration site conditions: Fever.
Nervous system disorders: Dizziness, headache.
Skin and subcutaneous tissue disorders: Alopecia.
Potentially Fatal: Granulocytopenia or pancytopenia.

PO: C

Evaluate pregnancy status in women of childbearing potential before therapy. Perform ophthalmic exams for the presence of retinal lesions before treatment initiation when used for neurocysticercosis. Monitor liver enzymes (transaminases) before the start of each treatment cycle and at least every 2 weeks during therapy. Monitor CBC with differential. Assess for signs and symptoms of cerebral hypertension, focal neurologic deficits or seizures.

Concurrent use with cimetidine, dexamethasone and praziquantel increases the plasma concentrations of albendazole sulfoxide (active metabolite). Concomitant use with carbamazepine, phenobarbital and phenytoin significantly decreases the concentration of albendazole sulfoxide.

Increased bioavailability with fatty meals or grapefruit juice.

Description:
Mechanism of Action: Albendazole, a benzimidazole derivative, binds to free β-tubulin in parasite cells. This results in selective inhibition of parasite microtubule polymerisation and inhibition of microtubule-dependent glucose uptake. Insufficient glucose causes a lack of adenosine triphosphate (ATP) resulting in the death of the parasite.
Pharmacokinetics:
Absorption: Poorly absorbed from the gastrointestinal tract. Increased bioavailability with a fatty meal. Time to peak plasma concentration: 2-5 hours (albendazole sulfoxide).
Distribution: Widely distributed throughout the body including bile, cyst fluid or wall, CSF, liver and urine. Enters breast milk. Plasma protein binding: 70%.
Metabolism: Metabolised in the liver via rapid sulfoxidation into albendazole sulfoxide (active metabolite), then further metabolised into albendazole sulfone and other primary oxidative metabolites. Undergoes extensive first-pass metabolism.
Excretion: Via urine (<1% as active metabolite); faeces. Elimination half-life: 8-12 hours (albendazole sulfoxide).

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2082, Albendazole. https://pubchem.ncbi.nlm.nih.gov/compound/Albendazole. Accessed May 28, 2024.

Store below 30°C.

Thuốc trừ giun sán

P02CA03 - albendazole ; Belongs to the class of benzimidazole derivative agents. Used as antinematodal.

Albendazole Tablet (Cipla USA Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 12/02/2024.

Albendazole. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 14/02/2024.

Anon. Albendazole. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 12/02/2024.

Anon. Albendazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/02/2024.

Buckingham R (ed). Albendazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/02/2024.

Champs D-Worms 200 mg Chocolate Flavour Chewable Tablet (Duopharma Manufacturing [Bangi] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 12/02/2024.

Denzol 200 mg Film Coated Tablet and 20 mg/mL Suspension (EIPICO). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 12/02/2024.

Idaman Pharma Albendazole Suspension 200 mg/5 mL (Idaman Pharma Manufacturing Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 12/02/2024.

Joint Formulary Committee. Albendazole. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/02/2024.

Thelban Tablet and Suspension (Biolab). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 12/02/2024.

Zenmox Chewable Tablet 200 mg (Y.S.P. Industries [M] Sdn Bhd). MIMS Malaysia. http://www.mims.com/malaysia. Accessed 12/02/2024.