News & Updates

Among adults with biopsy-confirmed metabolic dysfunction-associated steatohepatitis (MASH), treatment with glucagon-like peptide 1 receptor agonists (GLP-1RAs), particularly semaglutide or liraglutide, is associated with higher rates of MASH resolution without worsening of fibrosis compared with placebo, according to a recent Singapore study.

In the management of hypertension in paediatric chronic kidney disease (CKD), renin-angiotensin-aldosterone system inhibition (RAASi) is associated with better kidney function preservation and blood pressure control compared with calcium channel blockade, according to a real-world comparative-effectiveness study.

Metformin users appear to have a reduced risk of esophageal squamous cell carcinoma (ESCC) compared with nonusers, as shown in a population-based study.

Physicians across Southeast and East Asia describe significant gaps and inequalities in migraine care in the region, driven by specialist shortage, diagnostic delay, reliance on nonspecific medications, and limited access to migraine-specific therapies, as reflected in survey data from the SEALANT study.

Continuing denosumab beyond 10 years results in further increases in lumbar spine bone mineral density (BMD) and preserves femoral neck BMD, while switching to zoledronic acid leads to partial loss of previous gains and switching to romosozumab produces additional BMD gain at the lumbar spine, a cohort study in Hong Kong has shown.

Interventions such as aerobic exercise, intensive pharmacological reduction of cardiovascular (CV) risk factors, or both do not appear to provide significant improvements in cognitive function over 24 months in individuals at high risk of dementia, according to a randomized controlled trial.