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Oral antibiotics not inferior to IV-only therapy in blood, bone infections
Use of oral antibiotics in the treatment of osteomyelitis, bacteraemia, and infective endocarditis results in shorter hospital stay, has a better safety profile, and appears to be similarly effective when compared to intravenous (IV)-only therapy, a recent study has shown.

Abrocitinib effectively manages AD flares
Rescue therapy using the Janus kinase 1 inhibitor abrocitinib combined with topical medicated therapy recaptured efficacy responses and had a favourable safety profile in individuals with moderate-to-severe atopic dermatitis (AD) who experienced flare during the maintenance period of the phase III randomized-withdrawal JADE REGIMEN trial.

Intravenous brivaracetam safe in paediatric epilepsy
Treatment with intravenous brivaracetam is well tolerated in children with epilepsy, with a safety profile consistent with that known of the oral formulation, according to the results of a phase II study. There has been no pharmacokinetic difference observed when administered as bolus or a 15-minute infusion.

Omicron more stable than ancestral strain on surfaces, resistant to neutralizing mAbs
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is more stable than the ancestral strain on various smooth and porous surfaces and demonstrates marked resistance to neutralizing monoclonal antibodies (mAbs), researchers from the University of Hong Kong (HKU) have reported.

Eating fish helps keep stroke at bay, with caveats
Eating fish can reduce the risk of stroke, but the benefit is dictated by how fish is prepared and how often it is consumed, according to a study. Specifically, frequent consumption of baked or broiled fish is protective while regular consumption of fried fish contributes to a risk increase, which differs by socioeconomic status.

Inpatient service improves outcomes in mild acute pancreatitis
Implementation of an inpatient pancreatitis service appears to result in better outcomes in patients with mild acute pancreatitis, suggests a study. Guideline-based educational interventions deliver benefits on the management of this condition by admitting teams even without pancreatitis consultation.


