Tonolyte 2/Tonolyte 4: Side Effects & Dosing

Indications/Uses

Painful muscle spasm associated w/ static & functional disorders of the spine (cervical & lumbar syndromes) & following surgery (for herniated intervertebral disc or OA of the hip). Spasticity due to neurological disorders (eg, multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, CVA, cerebral palsy).

Dosage/Direction for Use

Painful muscle spasms 2-4 mg tid. Spasticity due to neurological disorders Max initial dose: 6 mg/day in 3 divided doses, then increase stepwise to 12-36 mg/day.

Contraindications

Hypersensitivity; concomitant therapy w/ ciprofloxacin or fluvoxamine.

Special Precautions

May impair ability to drive or operate machinery. Impaired kidney or liver function. Pregnancy & lactation. Childn.

Adverse Reactions

At low dose: Drowsiness, fatigue, dizziness, dry mouth, nausea, slight reduction in BP. At high dose: Muscle weakness, insomnia, bradycardia, hypotension, transient increase in serum transaminases.

View ADR Reporting Link

Drug Interactions

Antihypertensives including diuretics, ciprofloxacin, fluvoxamine, alcohol & sedatives.

MIMS Class

Muscle Relaxants

ATC Classification

M03BX02 - tizanidine ; Belongs to the class of other centrally-acting muscle relaxants.

Thai FDA Category

D

Presentation/Packing

Form

Tonolyte 2 tab 2 mg

Packing/Price

10 × 10's

Form

Tonolyte 4 tab 4 mg

Packing/Price

10 × 10's

Tonolyte 2/Tonolyte 4

tizanidine

Manufacturer:

Unison

Distributor:

F.C.P.

Marketer:

B.Grimm Pharma