Metrim Dosage & Drug Information

Concise Prescribing Info

Contents

Per tab Co-trimoxazole: Trimethoprim 80 mg, sulfamethoxazole 400 mg. Per 5 mL syr Co-trimoxazole: Trimethoprim 40 mg, sulfamethoxazole 200 mg

Indications/Uses

Infections from gm +ve, gm -ve & other susceptible microorganism eg, resp tract, GIT, GUT & skin infections, septicemia.

Dosage/Direction for Use

Tab Adult 2 tab bid. Long-term treatment: 1 tab bid. Syr Childn >2 mth Usual dose: TMP 40 mg/kg/day to 1 mL (TMP 8 mg, SMX 40 mg)/kg/day divided to bid. 10 kg 5 mL bid, 20 kg 10 mL bid, 30 kg 15 mL bid, 40 kg 20 mL bid.

Administration

Should be taken with food.

Contraindications

Severely impaired hepatic or renal function; hypersensitivity to sulfonamides, blood dyscrasias. Pregnancy & lactation. Infant <2 mth. Porphyria.

Special Precautions

Patients w/ folic acid deficiency, poor nutritional states or G6PD deficiency. Elderly & patients w/ reduced kidney function.

Adverse Reactions

GI disturbances; SJS & Lyell's syndrome. Rarely, hepatitis, blood disorders, Pseudomembranous colitis.

View ADR Reporting Link

Drug Interactions

Effects reduced by PABA & procaine-type local anaesth & enhanced by highly-bound drugs. May potentiate effects of MTX, warfarin, sulfonylureas.

MIMS Class

Antibacterial Combinations

ATC Classification

J01EE01 - sulfamethoxazole and trimethoprim ; Belongs to the class of combinations of sulfonamides and trimethoprim, including derivatives. Used in the systemic treatment of infections.

Thai FDA Category

Presentation/Packing

Form

Metrim syr

Packing/Price

60 mL x 1's

Form

Metrim tab

Packing/Price

10 × 10's;500's

Metrim

sulfamethoxazole + trimethoprim

Manufacturer:

Siam Bheasach

Distributor:

Siam Pharmaceutical