Memxa Dosage & Drug Information

Indications/Uses

Moderate to severe Alzheimer's disease.

Dosage/Direction for Use

Adult 5 mg/day on the 1st wk, 10 mg/day on the 2nd wk, then 15 mg/day on the 3rd wk. From the 4th wk on, treatment can be continued w/ the recommended maintenance dose of 20 mg/day. Max: 20 mg/day. Elderly 20 mg/day (10 mg bid or 20 mg once daily).

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to memantine.

Special Precautions

Epilepsy. Co-administration w/ NMDA-antagonists (eg, amantadine, ketamine or dextromethorphan). Careful monitoring of patients w/ factors that may raise urine pH. Recent MI, uncompensated CHF, uncontrolled HTN. Pregnancy & lactation.

Adverse Reactions

Agitation, inflicted injury, urinary incontinence, diarrhea, insomnia, dizziness, headache, hallucinations, fall, constipation, coughing. Tiredness.

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Drug Interactions

Levodopa, dopaminergic agonists, anticholinergics, barbiturates, neuroleptics, antispasmodic agents (dantrolene or baclofen), phenytoin, cimetidine, ranitidine, procainamide, quinidine, quinine, nicotine, hydrochlorothiazide. Avoid administration w/ amantadine, ketamine & dextromethorphan.

MIMS Class

Neurodegenerative Disease Drugs

ATC Classification

N06DX01 - memantine ; Belongs to the class of other anti-dementia drugs.

Thai FDA Category

S

Presentation/Packing

Form

Memxa FC tab 10 mg

Packing/Price

3 × 10's

Memxa

memantine

Manufacturer:

Unison

Distributor:

Medline

Marketer:

B.Grimm Pharma