Elaprase: Side Effects & Dosing

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage Patient Counseling Information MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Idursulfase

Indications/Uses

Hunter syndrome (mucopolysaccharidosis II).

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Dosage/Direction for Use

IV infusion 0.5 mg/kg every wk over a period of 1-3 hr. Max: 8 hr. Infusion rate: 8 mL/hr for the 1st 15 min, increase by 8 mL/hr increments at 15 min intervals. Max: 100 mL/hr.

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Overdosage

View Elaprase overdosage for action to be taken in the event of an overdose.

Special Precautions

Discontinue use immediately if anaphylactic or other acute reactions occur. Patients w/ compromised resp function or acute resp illness; susceptible to fluid overload or w/ acute underlying resp illness or compromised cardiac &/or resp function for whom fluid restriction is indicated. Pregnancy & lactation. Childn <16 mth. Elderly ≥65 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypersensitivity reactions including rash, urticaria, pruritus, flushing, pyrexia & headache, hypoxic episodes; diarrhea; musculoskeletal pain, headache; cough; pruritus, urticaria.

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Storage

View Elaprase storage conditions for details to ensure optimal shelf-life.

Description

View Elaprase description for details of the chemical structure and excipients (inactive components).

Action

View Elaprase mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Other Agents Affecting Metabolism

ATC Classification

A16AB09 - idursulfase ; Belongs to the class of enzymes. Used in the treatment of alimentary tract and metabolism problems.

Thai FDA Category

Patient Counseling Information

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Presentation/Packing

Form

Elaprase infusion soln 5 mL

Packing/Price

5 mL x 1's

Elaprase

idursulfase

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH