Eberil: Side Effects & Dosing

Indications/Uses

Acute & chronic pain (pain related to minor dental procedures, gynecological surgery, primary dysmenorrhea). Symptomatic relief of OA, RA, ankylosing spondylitis; pain & inflammation associated w/ gouty arthritis.

Dosage/Direction for Use

Acute pain 90 or 120 mg/day. Chronic pain 60 mg/day. OA 30 or 60 mg/day. RA & ankylosing spondylitis 60 or 90 mg/day. Gouty arthritis 120 mg/day. Mild hepatic impairment 60 mg/day. Moderate hepatic impairment Max: 30 mg once daily or 60 mg every other day.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity. CHF (NYHA II-IV), ischemic heart disease, peripheral arterial &/or cerebrovascular disease (including recent CABG surgery or angioplasty). Active peptic ulceration or GI bleeding, severe hepatic dysfunction; estimated CrCl <30 mL/min. History of allergic-type reaction to aspirin or other NSAIDs (eg, asthma, acute rhinitis, nasal polyps, angioneurotic oedema or urticaria). Pregnancy & lactation. Childn <16 yr.

Special Precautions

Lowest effective dose for shortest duration of time to reduce serious GI & CV events. Increased risk for thrombotic events & GI ulceration or other GI complications. Mild to moderate hepatic impairment.

Adverse Reactions

Edema, HTN; dizziness, fatigue, headache; abdominal pain, flatulence, diarrhea, dyspepsia, heartburn, nausea; increased ALT & AST; weakness.

View ADR Reporting Link

Drug Interactions

Increased effect of aminosalicylate derivatives, anticoagulants, bisphosphonate & estrogen derivatives. Increased effect w/ ACE inhibitors, alcohol, ARBs, TCAs. Decreased effect of ACE inhibitors, ARBs, β-blockers, SSRI. Decreased effect w/ CYP3A4 inducers.

MIMS Class

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

ATC Classification

M01AH05 - etoricoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.

Thai FDA Category

D

Presentation/Packing

Form

Eberil FC tab 120 mg

Packing/Price

3 × 10's

Form

Eberil FC tab 30 mg

Packing/Price

3 × 10's

Form

Eberil FC tab 60 mg

Packing/Price

3 × 10's;5 × 6's

Form

Eberil FC tab 90 mg

Packing/Price

3 × 10's

Eberil

etoricoxib

Manufacturer:

Unison

Distributor:

Medline

Marketer:

B.Grimm Pharma