Cefxitin: Side Effects & Dosing

Indications/Uses

Infection of intra-abdominal, intrapelvic, gynaecological, lower resp tract, bone & joint, skin & soft tissue, septicemia, UTI.

Dosage/Direction for Use

Adult 1-2 g 8 hrly. Can increase to 3 g 6 hrly. Patient w/ renal insufficiency Reduce dose. Infant >4 wk 20-40 mg/kg 6-8 hrly, 1-4 wk 20-40 mg/kg 8 hrly. Neonate ≤1 wk 20-40 mg/kg 12 hrly. Max dose: 12 g/day.

Contraindications

Hypersensitivity to cephamycin, cephalosporins & penicillin.

Special Precautions

Possible cross-sensitivity w/ other β-lactam antibiotics. Anaphylaxis. History of GI disease, particularly colitis. Renal impairment. Pregnancy & lactation.

Adverse Reactions

Thrombophlebitis, headache, dizziness, induration & tenderness following inj; rash, urticaria, pruritus, hypotension, pseudomembranous colitis, vomiting, leukopenia, eosinophilia, jaundice. Transient elevations in liver enzyme function tests.

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MIMS Class

Cephalosporins

ATC Classification

J01DC01 - cefoxitin ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.

Thai FDA Category

S

Presentation/Packing

Form

Cefxitin powd for inj 1 g

Packing/Price

1's

Cefxitin

cefoxitin

Manufacturer:

Siam Bheasach

Distributor:

Siam Pharmaceutical