Bilkate 5: Side Effects & Dosing

Indications/Uses

HTN & heart failure.

Dosage/Direction for Use

Adult HTN 5 mg once daily. May increase dose at intervals of 2 wk. Max: 40 mg once daily. Heart failure Initially 1.25 mg once daily. May double dose every 1-2 wk. Max: 10 mg once daily.

Administration

May be taken with or without food.

Contraindications

Sick-sinus syndrome, 2nd or 3rd degree heart block (w/o pacemaker), decompensated cardiac failure, severe bradycardia, cardiogenic shock, untreated phaeochromocytoma, metabolic acidosis, severe peripheral circulatory disturbances. History of bronchospasm & bronchial asthma. Hepatic impairment.

Special Precautions

Patients w/ inadequate cardiac function, well-compensated heart failure & myasthenia gravis. Patients undergoing major surgery involving general anaesth. May mask signs & symptoms of hypoglycaemia & hyperthyroidism. Abrupt w/drawal may exacerbate angina symptoms &/or precipitate MI & ventricular arrhythmias in patients w/ CAD. Pregnancy & lactation.

Adverse Reactions

Headache, paraesthesia, fatigue, asthenia, dizziness, diarrhoea, nausea, constipation, abdominal pain, insomnia, chest pain, bradycardia, dyspnoea, rash, & peripheral oedema, hypercholesterolaemia, hyperuricaemia, increased BUN, decreased HDL levels.

View ADR Reporting Link

Drug Interactions

Increased plasma conc w/ potent CYP2D6 inhibitors (eg, paroxetine, fluoxetine, propafenone, thioridazine, quinidine). May cause conduction disturbance w/ antiarrhythmics (eg, amiodarone, disopyramide) or nondihydropyridine Ca channel blockers (eg, diltiazem, verapamil). Additive -ve effects on AV conduction & heart rate w/ other β-adrenergic blockers or digoxin. May result in additive hypotension or bradycardia w/ catecholamine-depleting agents (eg, reserpine). May increase risk of rebound HTN w/ abrupt w/drawal of clonidine.

MIMS Class

Beta-Blockers

ATC Classification

C07AB12 - nebivolol ; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.

Thai FDA Category

D

Presentation/Packing

Form

Bilkate 5 tab 5 mg

Packing/Price

3 × 10's

Bilkate 5

nebivolol

Manufacturer:

Unison

Distributor:

Medline

Marketer:

B.Grimm Pharma