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Excessive IPFD ups risk of pancreatic diseases
Excessive intrahepatic fat deposition (IPFD) appears to contribute to an increased risk of major pancreatic disease, suggests a recent study, noting the potential benefits of IPFD reduction in preventing pancreatitis and pancreatic cancer.
Seladelpar delivers improvements in cholestatic biomarkers, pruritus in PBC patients
Treatment with seladelpar for up to 2 years improves cholestatic biomarkers and pruritus in patients with primary biliary cholangitis (PBC), with no serious safety concerns noted with long-term use, as shown by interim results of the ASSURE study.
Naltrexone–bupropion a safe weight-loss treatment for persons with obesity, depression
The extended-release combination of naltrexone and bupropion (NB-ER) may be used as safe and effective treatment for weight reduction among individuals with overweight/obesity and mild to moderate symptoms of depression, suggests a study.
Esketamine, rTMS and ECT: Which is more cost-effective in treatment-resistant depression?
Esketamine is more cost-effective than transcranial magnetic stimulation (rTMS) and electroconvulsive therapy (ECT), but not when compared with other commonly used third-line treatments for treatment-resistant depression (TRD) in Hong Kong, a multi-armed modelling study has shown.