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COVID-19 lockdown weakens metabolism in people with glucose intolerance
In Japan, the declaration of a state of emergency in response to the COVID-19 pandemic led to negative metabolic consequences in people with glucose intolerance, such as lowered skeletal muscle and increased body weight and body fat, a recent study has found.

Cathepsin S levels predict survival in NSTE-ACS patients
Circulating cathepsin S (CTSS) is significantly associated with long-term mortality and may be used to enhance risk stratification of patients with non–ST-segment elevation acute coronary syndrome (NSTE-ACS) over the Global Registry of Acute Coronary Events (GRACE) risk score, suggests a study.

Nine metabolic biomarkers can detect gastric cancer
Gastric cancer (GC) patients show an altered metabolic profile as compared with healthy individuals, a recent China study has found. A biomarker panel monitoring for nine metabolites can facilitate timely detection of GC.

CROWN: 1L lorlatinib improves PFS, reduces CNS progression in ALK-positive NSCLC ± brain metastases
First-line treatment of ALK-positive non-small-cell lung cancer (NSCLC) with lorlatinib improves progression-free survival (PFS) and reduces central nervous system (CNS) progression vs crizotinib, regardless of presence or absence of baseline brain metastases (BM), a post hoc analysis of the phase III CROWN trial has shown.




