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Liver enzymes mediate association of particulate matter exposure with diabetes risk

19 Oct 2022

Liver enzymes play a partial role in the relationship between exposure to particulate matter (PM) and risk of diabetes, indicating the involvement of lipid accumulation, oxidative stress, and chronic inflammation in the liver in its pathogenesis, reports a recent study.

19 Oct 2022

Lenvatinib-pembrolizumab combo fails to spring forward in HCC treatment

19 Oct 2022 by

In the phase III LEAP*-002 study, a combination regimen comprising lenvatinib and pembrolizumab appeared to have similar efficacy and safety as lenvatinib monotherapy as first-line therapy for advanced hepatocellular carcinoma (HCC).

19 Oct 2022

Human milk oligosaccharides tied to infant growth

19 Oct 2022 by

Levels of several human milk oligosaccharides (HMOs), such as 2’-fucosyllactose (2’FL) and lacto-N-tetraose (LNT), appear to correlate with measures of growth in breastfed infants, according to a recent Philippine study.

19 Oct 2022

Mitokine levels predict COPD outcomes

19 Oct 2022

In patients with chronic obstructive pulmonary disease (COPD), mitokine levels are elevated and are associated with important clinical outcomes such as disease exacerbation and exercise capacity, a recent study has found.

19 Oct 2022

Unhealthy lifestyle ups dental caries prevalence in teens with internet addiction

19 Oct 2022

Dental caries develop more often among adolescents with internet addiction (IA), an effect driven partly by unhealthy lifestyle behaviours, a recent Japan study has found.

19 Oct 2022

Fenfluramine a promising long-term treatment option for Lennox-Gastaut syndrome

19 Oct 2022

Treatment with fenfluramine produces sustained reductions in drop seizure frequency, especially generalized tonic-clonic seizures, in patients with Lennox-Gastaut syndrome (LGS), according to the results of an open-label extension trial.

19 Oct 2022

Trabectedin flops against advanced ovarian, uterine carcinosarcoma

19 Oct 2022

Trabectedin falls short of meeting the prespecified antitumour activity criteria in patients with advanced ovarian (OC) or uterine carcinosarcoma (UC), according to the results of a phase II trial. However, there appears to be a modest clinical benefit in a group of heavily pretreated patients.

19 Oct 2022

Rivaroxaban cuts radial artery occlusion rates

19 Oct 2022 by

Rivaroxaban reduces radial artery occlusion rate, without significantly increasing bleeds, in patients undergoing transradial coronary procedures in the RIVARAD study.

19 Oct 2022