News &amp; Updates

Circulating interleukin (IL)-17A in patients diagnosed with rheumatoid arthritis (RA) is associated with the incidence of cardiovascular disease (CVD), independent of traditional CVD risk factors and of erythrocyte sedimentation rate (ESR) at the time of diagnosis, suggests a study.

29 Aug 2024

Novel GLP-1/GCG receptor agonist shows promise against noncirrhotic MASH with fibrosis

Dual glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptor agonism with cotadutide has shown a signal of benefit in the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis, according to the phase II PROXYMO trial.

Add-on niraparib maintenance confers PFS benefit in endometrial cancer

29 Aug 2024 by

The addition of a PARP inhibitor (PARPi), niraparib, to dostarlimab plus chemotherapy significantly improved progression-free survival (PFS) among patients with primary advanced or recurrent endometrial cancer, including those with mismatch repair proficient (MMRp)/microsatellite stable (MSS) tumours, according to results from part 2 of the RUBY trial presented at ESMO Gyn 2024.

Dad’s preconception HBV infection tied to baby’s heart defects

A preconception history of hepatitis B virus (HBV) infection among fathers carries an increased risk of congenital heart disease (CHD) in offspring, as shown in a study.

28 Aug 2024

AI-based ECG predicts biventricular dysfunction, dilation in CHD

An ECG enhanced by artificial intelligence (AI) demonstrates its capability in detecting biventricular dysfunction and dilation in patients with congenital heart disease (CHD).

Rivaroxaban eases ischaemic events, ups bleeding in frail patients after revascularization

The risks of ischaemic complications and bleeding are higher among patients with peripheral artery disease (PAD) who meet the frailty criteria after lower extremity revascularization in the VOYAGER PAD study. Regardless of frailty status, use of rivaroxaban lowers the ischaemic risk and increases bleeding.

Skipping breakfast, night eating tied to faster weight gain

People who frequently skip breakfast and eat at night have faster increases in weight and waist circumference (WC), according to a China study.

Metformin, SGLT2is confer protection against dementia

Among various glucose-lowering medications, metformin and sodium glucose co-transporter-2 inhibitors (SGLT2is) are associated with a reduced risk of dementia, as shown in the results of a meta-analysis.

28 Aug 2024

Gestational diabetes linked to altered gut microbiome and larger head circumference in male offspring

Gestational diabetes mellitus (GDM) not only disrupts the gut microbiome of mothers and their infants, but is also linked to increased head circumference in male offspring, researchers from the Chinese University of Hong Kong (CUHK) have shown.

28 Aug 2024

Frontline ATRA-ATO regimen improves EFS in high-risk APL

The addition of arsenic trioxide (ATO) to all-trans retinoic acid (ATRA) with idarubicin significantly improves event-free survival (EFS) compared with ATRA plus chemotherapy (CHT) in the first-line setting for patients with newly diagnosed, high-risk acute promyelocytic leukaemia (APL), according to the APOLLO trial presented at EHA 2024.