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Childhood maltreatment increases schizophrenia risk 5-fold
Childhood maltreatment increases the risk of schizophrenia by five-fold, attention deficit hyperactivity disorder (ADHD) by 10-fold, and major depressive disorder (MDD) by nearly two-fold. It also leaves lasting genetic markers linked to neurodegenerative conditions, including Alzheimer’s disease and Parkinson’s disease, a Mendelian randomization study has shown.
Obefazimod hits targets in identical trials on active UC
Two phase III induction trials have demonstrated the efficacy and safety of obefazimod, an oral, first-in-class, small molecule, for the treatment of adults with moderate-to-severe ulcerative colitis (UC).
Multikingdom microbial biomarker test for autism risk assessment aids earlier diagnosis & intervention
Researchers from the Chinese University of Hong Kong (CUHK) have developed the world’s first artificial intelligence (AI)–powered multikingdom microbial biomarker test for autism spectrum disorder (ASD) risk assessment. By accurately excluding ASD in low-risk cases, the test may facilitate earlier diagnosis and intervention in high-risk groups.
Bladder preservation possible in select MIBC patients
Neoadjuvant chemotherapy (NAC) with transurethral resection (TUR) for bladder preservation is feasible for some patients with muscle-invasive bladder cancer (MIBC) who meet established selection criteria, suggests a study. However, recurrence may occur beyond 10 years, warranting lifetime surveillance.