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MRI- vs CT- guided radiotherapy for localized prostate cancer linked to lower toxicity, symptom burden
Magnetic resonance imaging (MRI) guidance in stereotactic body radiotherapy (SBRT) for prostate cancer offers significant advantage over computed tomography (CT) guidance, with lower physician-scored toxic effects and patient-reported symptom burden, according to the results of the phase III MIRAGE* study.
START-FIT: TACE + RT + avelumab promising as conversion therapy for locally advanced unresectable HCC
START-FIT, a prospective, single-arm, phase II trial, has found sequential transarterial chemoembolization (TACE) and stereotactic body radiotherapy (SBRT) followed by anti–PD-L1 treatment with avelumab to be a promising strategy for making patients with locally advanced unresectable hepatocellular carcinoma (HCC) amenable to curative treatment.
Diet with hyperinsulinaemic potential ups risk of breast cancer
Women with a dietary pattern contributing to hyperinsulinaemia and insulin resistance appear to be at increased risk of breast cancer, particularly estrogen-receptor (ER)-negative and human epidermal growth factor receptor 2 (HER2)-enriched tumours, reveals a study.
PFS in relapsed/refractory CLL/SLL: Zanubrutinib triumphs over ibrutinib
The second-generation BTK* inhibitor zanubrutinib was superior to the standard-of-care ibrutinib in improving progression-free survival (PFS) among patients with relapsed/refractory chronic lymphocytic leukaemia (R/R CLL) or small lymphocytic lymphoma (SLL), according to results of the phase III ALPINE trial presented at ASH 2022.
KRAS G12C inhibitors show promise in metastatic colorectal and pancreatic cancers
The KRASG12C inhibitors, adagrasib and sotorasib, have shown promising antitumour activity in patients with heavily pretreated metastatic colorectal cancer (mCRC) and metastatic pancreatic cancer, respectively.
Recent hyperglycaemia helps detect pancreatic cancer early
Pancreatic cancer may be identified early if assessment will be steered towards the point of recent hyperglycaemia based on elevated HbA1c, suggests a retrospective cohort study, noting that such early detection may then improve survival in cancer patients.