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Takotsubo syndrome tied to impaired LV contractility, shortened systolic period
Patients with Takotsubo syndrome (TTS), a reversible form of heart failure with incompletely understood pathophysiology, may exhibit reduced cardiac contractility, shortened systolic period, inefficient energetics, and prolonged active relaxation but unaffected diastolic passive stiffness, a study has shown.

Triple, quadruple combos a useful strategy for early management of hypertension
Low-dose drug combinations that incorporate between three and four blood pressure (BP)-lowering medications appear to be well tolerated and effective for the initial or early management of hypertension, according to the results of a systematic review and meta-analysis.

Rivaroxaban for prophylactic anticoagulation in COVID-19 strikes out
The use of rivaroxaban in nonhospitalized patients with symptomatic COVID-19 falls short of reducing the composite endpoint of venous and arterial thrombotic events, hospitalization, and death, according to data from PREVENT-HD*.

Influenza vaccine wards off cardiovascular events, death in CAD patients
A meta-analysis of randomized trials has revealed that influenza vaccination is effective at preventing all-cause mortality, cardiovascular mortality, major acute cardiovascular events, and acute coronary syndrome (ACS) among patients with coronary artery disease (CAD), particularly in those with ACS.

Mid-dose beta-blocker therapy tied to highest mortality reduction after AMI
Use of any beta-blocker dose results in a significant decrease in mortality following acute myocardial infarction (AMI) when compared with no treatment, reports a study. Doses >25 percent to 50 percent of the currently recommended target dose (RTD) are associated with highest mortality reduction within the first year after AMI, indicating that higher doses are not required.



