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Adipose tissue–targeted nanoparticles may improve treatment of obesity and atherosclerosis
Researchers from the University of Hong Kong (HKU) have developed a nanoparticle-based targeted drug delivery system that selectively transports thyroid hormone (TH) to adipose tissue, which may improve treatment of obesity and its related cardiometabolic complications by overcoming serious adverse events (AEs) associated with systematic TH administration.

Tighter BP control improves pregnancy outcomes in women with DM, chronic hypertension
Further lowering blood pressure helps cut the risk of adverse perinatal events for pregnant women with pregestational diabetes mellitus (DM) and mild chronic hypertension, according to the secondary analysis of the Chronic Hypertension and Adverse Pregnancy (CHAP) study presented at SMFM 2023.

Fracture risk not higher with SGLT2 vs DPP4 inhibitors
The use of sodium-glucose transporter 2 (SGLT2) inhibitors among patients with diabetes does not pose an increased risk of developing fractures as compared with dipeptidyl-peptidase 4 (DPP4) inhibitors, and this is true across estimated glomerular filtration rate (eGFR) and albuminuria categories, as shown in a study.

Treat childhood obesity promptly—AAP
Paediatricians and other healthcare providers should treat childhood obesity immediately and at the highest level of intensity appropriate for and available to children, according to the new guideline published by the American Academy of Pediatrics (AAP).




