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Optimizing anticoagulation therapy for atrial fibrillation with prior gastrointestinal bleeding

24 Jul 2022 by

Long-term anticoagulation therapy is often recommended for patients with atrial fibrillation (AF) to reduce their risk of stroke, but gastrointestinal bleeding (GIB) is a common complication that presents a significant challenge. Patients with a history of GIB have heightened risks of recurrent bleeding events, hence interruption or discontinuation of anticoagulants is often warranted. When and how to restart anticoagulant therapy following an episode of GIB has been debated. MIMS Doctor interviewed Dr Pipin Kojodjojo, Cardiologist and Cardiac Electrophysiologist at Asian Heart & Vascular Centre, Singapore, to gather his perspectives on how to manage anticoagulant therapy after a GIB episode.

Optimizing anticoagulation therapy for atrial fibrillation with prior gastrointestinal bleeding

24 Jul 2022

Bilirubin levels inversely associated with new-onset hypertension in perimenopause

23 Jul 2022

Among perimenopausal women, lower total bilirubin concentrations may indicate an increased likelihood of new-onset hypertension, as reported in a cross-sectional study.

Bilirubin levels inversely associated with new-onset hypertension in perimenopause

23 Jul 2022

Increasing cardiac symptoms, healthcare use could be warning signs of sudden cardiac death

23 Jul 2022

In patients with heritable cardiac disease arrhythmogenic right ventricular cardiomyopathy (ARVC), mounting cardiac symptoms and healthcare use seem to precede sudden cardiac death (SCD), a recent study has found.

Increasing cardiac symptoms, healthcare use could be warning signs of sudden cardiac death

23 Jul 2022

Tafamidis still the only approved therapy for ATTR-CM in Asia

23 Jul 2022 by

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressively debilitating disease with a formidable symptom burden and an average survival of 2–5 years from diagnosis. In 2019, the US Food and Drug Administration approved tafamidis (Vyndamax) as the first disease-modifying therapy for ATTR-CM. Since then, tafamidis has been approved for the treatment of ATTR-CM in over 55 countries including Japan, Australia, and Singapore. MIMS Doctor interviewed Dr Tang Hak Chiaw, consultant cardiologist at Novena Heart Centre, Singapore, about the types and clinical presentation of ATTR-CM in Singapore, and the role of tafamidis in the treatment of this often underdiagnosed and fatal disease of the heart muscle.

Tafamidis still the only approved therapy for ATTR-CM in Asia

23 Jul 2022

Genetic risk score for high SBP does not predict poor hypertension control

22 Jul 2022

Use of a genetic risk score (GRS) for high systolic blood pressure (SBP) does not appear to forecast hypertension control, according to a study.

Genetic risk score for high SBP does not predict poor hypertension control

22 Jul 2022

Prediabetes may up MI, PCI, CABG risk

21 Jul 2022 by

Individuals with prediabetes appear to be at an elevated risk of developing myocardial infarction (MI) as well as requiring coronary interventions, according to a study presented at ENDO 2022.

Prediabetes may up MI, PCI, CABG risk

21 Jul 2022

Lifestyle changes improve cognition among people with resistant hypertension

21 Jul 2022

Individuals with resistant hypertension who undergo lifestyle modification have better cognitive function, and this benefit may be attributed to the reduced ambulatory systolic blood pressure (SBP) changes through weight loss, suggests a study.

Lifestyle changes improve cognition among people with resistant hypertension

21 Jul 2022

Pre-eclampsia ups risk of nonsyndromic orofacial clefts

21 Jul 2022

Only pre-eclampsia, among other hypertensive disorders of pregnancy, contributes to a higher risk of nonsyndromic orofacial clefts (NSOFCs) and its subtypes, a study has found.

Pre-eclampsia ups risk of nonsyndromic orofacial clefts

21 Jul 2022

Cutting sedentary time improves cardiometabolic outcomes

21 Jul 2022 by

Reducing sedentary behaviour (SB) by about an hour – without intentionally incorporating exercise or any moderate-to-vigorous physical activity (MVPA) into a daily regimen – improved cardiometabolic outcomes in adults with metabolic syndrome (MetS), a Finnish study suggests.

Cutting sedentary time improves cardiometabolic outcomes

21 Jul 2022

Integrated care teams improve outcomes, processes in patients with noncommunicable disease

20 Jul 2022 by

Implementation of an integrated care team (ICT) in primary care results in enhanced clinical and process outcomes relative to usual care (UC), with more patients who have noncommunicable disease achieving treatment goals at 1 year, a Singapore study has shown.

Integrated care teams improve outcomes, processes in patients with noncommunicable disease

20 Jul 2022

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Optimizing anticoagulation therapy for atrial fibrillation with prior gastrointestinal bleeding

Optimizing anticoagulation therapy for atrial fibrillation with prior gastrointestinal bleeding

Bilirubin levels inversely associated with new-onset hypertension in perimenopause

Bilirubin levels inversely associated with new-onset hypertension in perimenopause

Increasing cardiac symptoms, healthcare use could be warning signs of sudden cardiac death

Increasing cardiac symptoms, healthcare use could be warning signs of sudden cardiac death

Tafamidis still the only approved therapy for ATTR-CM in Asia

Tafamidis still the only approved therapy for ATTR-CM in Asia

Genetic risk score for high SBP does not predict poor hypertension control

Genetic risk score for high SBP does not predict poor hypertension control

Prediabetes may up MI, PCI, CABG risk

Prediabetes may up MI, PCI, CABG risk

Lifestyle changes improve cognition among people with resistant hypertension

Lifestyle changes improve cognition among people with resistant hypertension

Pre-eclampsia ups risk of nonsyndromic orofacial clefts

Pre-eclampsia ups risk of nonsyndromic orofacial clefts

Cutting sedentary time improves cardiometabolic outcomes

Cutting sedentary time improves cardiometabolic outcomes

Integrated care teams improve outcomes, processes in patients with noncommunicable disease

Integrated care teams improve outcomes, processes in patients with noncommunicable disease