Tazocin: Side Effects & Dosing

Information is sourced from publicly available references. The information is for educational purpose of healthcare professionals and we are not liable for any loss or damage.

Core Prescribing Info

Contents

Piperacillin 4 g, tazobactam 500 mg

Indications/Uses

Lower resp tract, intra-abdominal, skin & skin structure infections; complicated & uncomplicated UTI; bacterial septicemia. Polymicrobial infections. Bacterial infections in neutropenic adults or childn in combination w/ aminoglycoside. Intra-abdominal infections including appendicitis complicated by rupture or abscess, peritonitis & biliary infections in hospitalized childn 2-12 yr.

Dosage/Direction for Use

IV Adult & childn >12 yr 4.5 g 8 hrly. Total daily dose: 2.25-4.5 g every 6-8 hr. Neutropenia 4.5 g 6 hrly in combination w/ aminoglycoside. Childn <12 yr weighing >50 kg Adult dose, <50 kg Adjusted dose: 90 mg/kg 6 hrly in combination w/ aminoglycoside. Intra-abdominal infection Hospitalized childn 2-12 yr weighing up to 40 kg 112.5 mg/kg 8 hrly, >40 kg 4.5 g 8 hrly. Renal insufficiency in adult & childn weighing >50 kg w/ CrCl 20-80 mL/min 4 g/500 mg 8 hrly in divided doses, <20 mL/min 4 g/500 mg 12 hrly in divided doses; <50 kg w/ CrCl 40-80 mL/min 90 mg/kg 6 hrly, 20-40 mL/min 90 mg/kg 8 hrly, <20 mL/min 90 mg/kg 12 hrly. Childn <50 kg on hemodialysis 45 mg/kg 8 hrly. Duration of therapy: Min: 5 days. Max: 14 days. All doses to be given by slow IV inj over at least 3-5 min or slow IV infusion over 20-30 min.

Contraindications

Hypersensitivity to β-lactams (including penicillins & cephalosporins) or β-lactamase inhibitors.

MIMS Class

Penicillins

ATC Classification

J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Regulatory Classification

POM

Presentation/Packing

Form

Tazocin powd for soln for inj 4.5 g

Packing/Price

1's

Tazocin

piperacillin + tazobactam

Manufacturer:

Wyeth Lederle