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Indications and Dosage
Topical/Cutaneous
Tinea versicolor Adult: As 2.5% susp: Apply undiluted onto the affected area(s) and leave on for 10 minutes, then rinse thoroughly. Repeat once daily for 1 week. Topical/Cutaneous Dandruff, Seborrhoeic dermatitis Adult: As 1% shampoo/lotion or 2.5% susp: Apply onto wet hair and scalp, then rinse thoroughly. Use at least twice weekly.
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What are the brands available for Selenium sulfide in Singapore?
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Special Precautions
Pregnancy and lactation.
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Adverse Reactions
Significant: Skin irritation or sensitisation.
General disorders and administration site conditions: Application-site irritation. Skin and subcutaneous tissue disorders: Skin discolouration, hair discolouration, hair thinning; oiliness or dryness of the scalp or hair. |
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Topical: C
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Patient Counseling Information
Avoid contact with the eyes. Do not apply to inflamed or damaged skin or mucous membranes.
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Monitoring Parameters
Assess for signs and symptoms of severe skin irritation.
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Action
Description:
Overview: Selenium sulfide is an anti-infective agent with antifungal and antiseborrhoeic properties. Mechanism of Action: Selenium sulfide is believed to inhibit the enzymes involved in the growth of epithelial tissue upon absorption into the epithelial tissue. Additionally, it appears to have a cytostatic action on cells of the epidermis and follicular epithelium which results in decreased corneocyte production. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 24011, Selenium sulfide (SeS). https://pubchem.ncbi.nlm.nih.gov/compound/Selenium-sulfide-_SeS. Accessed Nov. 26, 2025. |
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Storage
Store between 15-30°C. Shake well before use.
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ATC Classification
D01AE13 - selenium sulfide ; Belongs to the class of other antifungals for topical use.
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References
Brayfield A, Cadart C (eds). Selenium Sulfide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 17/10/2025. Head and Shoulders 2 in 1 Clinical Strength Cooling Itch Relief Lotion/Shampoo (The Procter & Gamble Manufacturing Company). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 17/10/2025. Joint Formulary Committee. Selenium. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 17/10/2025. Meijer Medicated Anti-dandruff Shampoo (Meijer Distribution, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 17/10/2025. Selenium Sulfide 2.5% Lotion (Padagis Israel Pharmaceuticals Ltd). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 20/11/2025. Selenium Sulfide. UpToDate Lexidrug, AHFS DI (Adult and Pediatric) Online. American Society of Health-System Pharmacists, Inc. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 17/10/2025. Selenium Sulfide. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 17/10/2025. Selsun 2.5% Suspension (Rohto-Mentholatum [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 17/10/2025.
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