Quetiapine Sandoz

Schizophrenia. Acute manic episodes associated w/ bipolar I disorder. Depressive episodes associated w/ bipolar disorder. Recurrence prevention in maintenance treatment of bipolar I disorder (manic, mixed or depressive episode) as monotherapy or in combination w/ lithium or valproate.

Adult Schizophrenia Doses to be given bd. Total daily dose for the 1st 4 days: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3) & 300 mg (day 4). From day 4 onwards, titrate dose to a range of 300-450 mg daily. Dose may be adjusted w/in the range of 150-750 mg daily. Manic episodes associated w/ bipolar disorder Doses to be given bd. Total daily dose for the 1st 4 days: 100 mg (day 1), 200 mg (day 2), 300 mg (day 3), 400 mg (day 4). Further dosage adjustments up to 800 mg daily by day 6 should be in increments of no >200 mg daily. Dose may be adjusted within the range of 200-800 mg daily. Usual effective dose: 400-800 daily. Depressive episodes associated w/ bipolar disorder Doses to be given once daily at bedtime. Daily dose for the 1st 4 days: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3), 300 mg (day 4). May titrate dose to 400 mg (day 5) up to 600 mg (day 8). Recurrence prevention in maintenance treatment of bipolar I disorder May re-adjust dose depending on clinical response & tolerability w/in range of 400-800 mg daily. Elderly, renal & hepatic impairment Initially 25 mg daily. Increase dose daily in increments of 25-50 mg to an effective dose.

May be taken with or without food.

Hypersensitivity.

Antipsychotics

N05AH04 - quetiapine ; Belongs to the class of diazepines, oxazepines and thiazepines antipsychotics.

POM