Ezetrol

Monotherapy or in combination w/ an HMG-CoA reductase inhibitor (statin) as an adjunct to diet for reduction of elevated total-C, LDL-C & Apo B in patients w/ primary hypercholesterolemia. In combination w/ fenofibrate as an adjunct to diet for reduction of elevated total-C, LDL-C, Apo B & non-HDL-C in patients w/ mixed hyperlipidemia. In combination w/ atorvastatin or simvastatin for reduction of elevated total-C & LDL-C in patients w/ HoFH as an adjunct to other lipid-lowering treatments (eg, LDL apheresis) or if such treatments are unavailable. Adjunctive therapy to diet for reduction of elevated sitosterol & campesterol levels in patients w/ homozygous familial sitosterolemia.

Recommended dose: 10 mg once daily. Co-administration w/ bile acid sequestrants Administer ≥2 hr before or ≥4 hr after the bile acid sequestrant. Patient w/ CKD & estimated GFR <60 mL/min/1.73 m² Combination therapy w/ simvastatin Ezetrol 10 mg & simvastatin 20 mg once daily in the evening.

May be taken with or without food.

Hypersensitivity. In combination w/ statin in patients w/ active liver disease or unexplained persistent elevations in serum transaminases. Co-administration w/ statin & fenofibrate during pregnancy & lactation.

Dyslipidaemic Agents

C10AX09 - ezetimibe ; Belongs to the class of other lipid modifying agents.

POM