Daptomycin Anfarm

Adult & paed (1-17 yr) patients w/ complicated skin & skin structure infections (cSSSI) caused by susceptible isolates of gram +ve bacteria including Staph aureus (including methicillin-resistant isolates), Strep pyogenes, Strep agalactiae, Strep dysgalactiae subsp. equisimilis & Enterococcus faecalis (vancomycin-susceptible isolates only). Adult patients w/ Staph aureus bloodstream infections (bacteremia), including those w/ right-sided infective endocarditis (SAB/RIE), caused by methicillin-susceptible & -resistant isolates. Ped patients (1-17 yr) w/ Staph aureus bloodstream infections (bacteremia) caused by methicillin-susceptible & -resistant isolates.

IV cSSSI Adult 4 mg/kg every 24 hr for 7-14 days, administer by inj over 2-min or infusion over 30-min. Adult w/ renal impairment CrCl ≥30 mL/min 4 mg/kg every 24 hr, <30 mL/min 4 mg/kg every 48 hr. Duration of therapy: 7-14 days. Childn 12-17 yr 5 mg/kg every 24 hr infused over 30 min, 7-11 yr 7 mg/kg every 24 hr infused over 30 min, 2-6 yr 9 mg/kg every 24 hr infused over 60 min. Duration of therapy: Up to 14 days. SAB Adult 6 mg/kg every 24 hr for 2-6 wk, administer by inj over 2-min or infusion over 30-min. Childn 12-17 yr 7 mg/kg every 24 hr infused over 30 min, 7-11 yr 9 mg/kg every 24 hr infused over 30 min, 2-6 yr 12 mg/kg every 24 hr infused over 60 min. Duration of treatment: Up to 42 days. SAB/RIE Adult w/ renal impairment CrCl ≥30 mL/min 6 mg/kg every 24 hr, <30 mL/min 6 mg/kg every 48 hr. Duration of therapy: 2-6 wk.

Hypersensitivity.

Other Antibiotics

J01XX09 - daptomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.

POM