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PANTHER 10-year data support tailored dose-dense adjuvant chemo for high-risk early breast cancer
Long-term data from the phase III PANTHER trial demonstrate improved breast cancer recurrence-free survival (BCRFS) with tailored dose-dense adjuvant chemotherapy as opposed to standard adjuvant chemo in individuals with high-risk early breast cancer.

Subcutaneous amivantamab compares favourably with intravenous dosing in EGFR-mutant NSCLC
In previously treated patients with EGFR-mutated advanced non-small-cell lung cancer (NSCLC), subcutaneous (SC) amivantamab combined with lazertinib shows noninferior pharmacokinetic and efficacy profiles compared with the approved intravenous (IV) formulation of amivantamab, according to the phase III PALOMA-3 trial.

Trastuzumab deruxtecan delivers long-term survival in HER2+ breast cancer
HER2-positive metastatic breast cancer (mBC) patients who had been treated with trastuzumab emtansine continue to enjoy survival benefits with trastuzumab deruxtecan (TD) relative to those who received treatment of physician’s choice (TPC), as shown by the updated results of the DESTINY-Breast (DB)-02 study. TD also boasts of a manageable safety profile, with no long-term toxicity.

NMR helps tailor treatment for smoking cessation in smokers with COPD
Among smokers with chronic obstructive pulmonary disease (COPD), use of varenicline seems better than bupropion in normal metabolizers, but bupropion displays similar efficacy and less side effects in slow metabolizers, reports a study.




