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Biologics prevent infection-related hospitalization in IBD patients with comorbidity
Treatment with vedolizumab or ustekinumab leads to reduced rates of infection-related hospitalization compared with antitumour necrosis factor-α antagonists (anti-TNF) among adults with inflammatory bowel disease (IBD) initiating biologic therapy and with high comorbidity burden, reports a recent study.

High-flow oxygen does not reduce mortality in COVID-19 respiratory failure
The use of high-flow nasal cannula oxygen, as opposed to standard oxygen, in the first-line setting, did not reduce mortality rates in patients admitted to intensive care units (ICUs) for respiratory failure due to COVID-19, results of the SOHO-COVID trial showed.

CRT vs SBRT: Which approach yields better outcomes in PDAC?
Multiagent chemotherapy (MAC) followed by conventionally fractionated radiotherapy (CRT) shows rates of margin-negative resection (R0) and pathologic complete response similar to those of MAC plus stereotactic body radiotherapy (SBRT) in patients with localized pancreatic ductal adenocarcinoma (PDAC), according to a study. However, MAC plus CRT is associated with less regional lymphatic disease.

Long-term relugolix combo helps with heavy periods, anaemia in women with uterine fibroids
Treatment with relugolix combination for up to 52 weeks yields sustained reductions in heavy menstrual bleeding as well as subsequent increases in iron stores in women with uterine leiomyomas, as shown in a study.





