News & Updates

Mitapivat, a first-in-class, oral, allosteric activator of pyruvate kinase (PK), breaks new ground in the global phase III ENERGIZE study, the first trial to demonstrate the potential of an oral treatment for both alpha- and beta-non-transfusion-dependent thalassemia (NTDT).

A 10-week study presented at EAN 2024 has shown that a ketogenic or “keto” diet plus regular physical exercise may be beneficial for people with narcolepsy.

New drug applications approved by US FDA as of 16-30 June 2024 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Ivonescimab plus chemotherapy has a tolerable safety profile and appears to significantly prolong progression-free survival (PFS) in patients with nonsmall cell lung cancer (NSCLC) whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, according to interim data from the phase III HARMONi-A study.

In patients with acute severe ulcerative colitis (UC), the addition of tofacitinib to corticosteroids results in better response to treatment, reveals a study. This benefit persists beyond 7 days, as shown by the lower rates of medical or surgical rescue therapy at 90 days.

Specific antipsychotic drugs such as high-dose quetiapine, high- and medium-dose clozapine, and high-dose olanzapine appear to be associated with a heightened risk of pneumonia among patients with schizophrenia, as shown in a study.

Osimertinib extends progression-free survival (PFS) sevenfold longer than placebo in patients with unresectable stage III EGFR-mutated non–small cell lung cancer (NSCLC) following definitive chemoradiotherapy, as shown in the primary analysis of the phase III LAURA study presented at ASCO 2024. This breakthrough makes osimertinib the first EGFR inhibitor to show benefit in a stage III setting.