News &amp; Updates

Hard physical activity and normotensive individuals and increasing systolic blood pressure (SBP) in those with hypertension each correlate with larger thoracic aortic size, suggests a study.

Physical activity, SBP tied to thoracic aortic size

08 Oct 2024

Doxorubicin-trabectedin a ray of hope for advanced or metastatic LMS

08 Oct 2024 by

In the phase III LMS04 trial, induction therapy with doxorubicin and trabectedin, followed by trabectedin maintenance, improved survival in patients with metastatic or surgically unresectable soft-tissue or uterine leiomyosarcoma (LMS).

Doxorubicin-trabectedin a ray of hope for advanced or metastatic LMS

Excess weight in women, men ups risk of subfertility and pregnancy loss

For both women and men, BMI that is outside of the normal category during the preconception or early-pregnancy periods is a risk factor for lower fecundability, subfertility, and miscarriage, as reported in a cohort study.

Excess weight in women, men ups risk of subfertility and pregnancy loss

Which factors predict pregnancy outcomes in SLE?

In women with systemic lupus erythematosus (SLE), factors such as disease activity prior to and during conception as well as the presence of secondary antiphospholipid syndrome convey heightened risk of adverse pregnancy outcomes, according to the results of a systematic review and meta-analysis.

Which factors predict pregnancy outcomes in SLE?

Sacubitril/valsartan vs enalapril for paediatric HF a toss-up in head-to-head trial

Sacubitril/valsartan appears to be safe and beneficial in the treatment of children with heart failure (HF) attributable to systemic left ventricular systolic dysfunction (LVSD), with the drug having comparable efficacy as enalapril, according to the 52-week data from the phase 2/3 PANORAMA-HF* trial.

Sacubitril/valsartan vs enalapril for paediatric HF a toss-up in head-to-head trial

Pharmacist-led telemedicine improves adherence, reimbursements in clinics

A pharmacist-managed telemedicine during the COVID-19 pandemic has resulted in improvements in appointment adherence in the hospital-based (HB) clinic and increased reimbursement in the physician-based (PB) clinic, reports a study. Healthcare outcomes, however, show no significant change.

Pharmacist-led telemedicine improves adherence, reimbursements in clinics

Osimertinib after CRT safe, effective in unresectable stage III EGFR-mutated NSCLC

Treatment with osimertinib following definitive chemoradiotherapy (CRT) demonstrates a manageable safety profile in patients with unresectable stage III EGFR-mutated nonsmall cell lung cancer (NSCLC), reports a study presented at WCLC 2024.

Osimertinib after CRT safe, effective in unresectable stage III EGFR-mutated NSCLC

07 Oct 2024

New model predicts HCC risk in noncirrhotic CHB patients

A novel prognostic model based on the viral loads of hepatitis B virus (HBV) demonstrates its utility in predicting and stratifying the risk of hepatocellular carcinoma (HCC) in noncirrhotic patients with chronic hepatitis B (CHB) who are not yet receiving antiviral therapy.

New model predicts HCC risk in noncirrhotic CHB patients

07 Oct 2024

CO₂ laser excision a novel treatment approach for large xanthelasma lesions

A study has shown that carbon dioxide (CO₂) laser excision may be an innovative approach for treating xanthelasma palpebrarum (XP), particularly for large lesions.

CO₂ laser excision a novel treatment approach for large xanthelasma lesions

Darolutamide + ADT, without docetaxel, shows efficacy benefits in mHSPC