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TriClip device gets FDA nod for leaky heart valve

10 Apr 2024 by

The US Food and Drug Administration (FDA) has approved the TriClip device for transcatheter edge-to-edge repair (TEER) in patients with severe tricuspid regurgitation (TR) or a leaky heart valve who are not eligible for surgery.

TriClip device gets FDA nod for leaky heart valve

10 Apr 2024

APOC3 inhibition shows therapeutic potential in severe hypertriglyceridemia

10 Apr 2024 by

Treatment with plozasiran, an experimental small interfering–RNA drug that targets apolipoprotein C3 (APOC3) gene, helps regulate triglyceride levels, bringing them below the critical threshold associated with acute pancreatitis for most patients with severe hypertriglyceridemia, according to the phase IIb SHASTA-2* study.

APOC3 inhibition shows therapeutic potential in severe hypertriglyceridemia

10 Apr 2024

Aprocitentan gets FDA nod for uncontrolled HTN

10 Apr 2024 by

The US Food and Drug Administration (FDA) has approved aprocitentan for the treatment of uncontrolled hypertension (HTN) in adults.

Aprocitentan gets FDA nod for uncontrolled HTN

10 Apr 2024

ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

10 Apr 2024

Gartisertib, an oral inhibitor of ataxia telangiectasia and Rad3-related protein (ATR), for patients with advanced solid tumours is well tolerated at lower doses, according to the results of a phase I study. However, unexpected liver toxicity prevents dose escalation and, in turn, limits the drug’s antitumour activity.

ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

10 Apr 2024

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

09 Apr 2024 by

Statin therapy appears to result in a modest elevation in blood sugar levels, increasing the likelihood of diabetes development especially among people whose blood sugar levels are already near the diagnostic threshold, according to a meta-analysis.

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

09 Apr 2024

2 drugs in 1 pill better than complex regimens for HIV

09 Apr 2024 by

The combination of bictegravir and lenacapavir, taken orally once daily, performed better than current complex treatment regimens in the phase II ARTISTRY-1 trial of people with HIV who are virologically suppressed.

2 drugs in 1 pill better than complex regimens for HIV

09 Apr 2024

Asthma control better with dupilumab-ICS combo

09 Apr 2024 by

Adding the anti-interleukin-4 receptor alpha monoclonal antibody dupilumab to an inhaled corticosteroid (ICS) reduces asthma exacerbations and improves lung function in a post hoc analysis of the LIBERTY ASTHMA QUEST trial.

Asthma control better with dupilumab-ICS combo

09 Apr 2024

Novel drug significantly cuts triglyceride levels

08 Apr 2024 by

The investigational RNAi therapeutic plozasiran significantly reduced triglyceride levels in individuals with severe hypertriglyceridaemia (SHTG) who were at high risk for pancreatitis, according to the final results of the phase IIb SHASTA-2 trial.

Novel drug significantly cuts triglyceride levels

08 Apr 2024

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

07 Apr 2024

Adding desloratadine to an isotretinoin regimen appears to reduce pruritus in acne, leading to a higher patient satisfaction, as shown in a study.

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

07 Apr 2024

Filgotinib for ulcerative colitis holds up in real world

07 Apr 2024

The oral Janus kinase (JAK) 1 preferential inhibitor filgotinib appears to be safe and effective in the treatment of Asian patients with ulcerative colitis, according to real-world data.

Filgotinib for ulcerative colitis holds up in real world

07 Apr 2024

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TriClip device gets FDA nod for leaky heart valve

TriClip device gets FDA nod for leaky heart valve

APOC3 inhibition shows therapeutic potential in severe hypertriglyceridemia

APOC3 inhibition shows therapeutic potential in severe hypertriglyceridemia

Aprocitentan gets FDA nod for uncontrolled HTN

Aprocitentan gets FDA nod for uncontrolled HTN

ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

ATR inhibitor promise for advanced solid tumours dimmed by liver toxicity

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

Statins linked to moderate increase in diabetes risk, but overall benefits bear more weight

2 drugs in 1 pill better than complex regimens for HIV

2 drugs in 1 pill better than complex regimens for HIV

Asthma control better with dupilumab-ICS combo

Asthma control better with dupilumab-ICS combo

Novel drug significantly cuts triglyceride levels

Novel drug significantly cuts triglyceride levels

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

Add-on desloratadine helps reduce acne itching, improve treatment satisfaction

Filgotinib for ulcerative colitis holds up in real world

Filgotinib for ulcerative colitis holds up in real world