Vit A: Dermatitis & photosensitivity reactions. Vit C: Diarrhea (doses ≥1 g daily), nausea, vomiting, abdominal cramps, heartburn, transient colic, flatulent distension, fatigue, flushing, headache, insomnia, sleepiness, mild increase in urination. Acidification of urine; precipitation of urate, cystine, oxalate stones or drugs in the urinary tract. Hemolysis in patients w/ G6PD deficiency (large doses). Vit E: Myopathy, HTN, thrombophlebitis, gonadal dysfunction, breast soreness, gynecomastia, creatinuria; increased serum creatine kinase, serum cholesterol & triglycerides; increased urinary estrogens & androgens; thyroid problems. Increased bleeding tendency in vit K-deficient patients eg, taking oral anticoagulants (doses >1,000 mg daily for prolonged periods). Increased risk of thrombosis eg, those taking estrogens. Se: Abdominal pain & cramps, diarrhea, nausea, vomiting, garlic-like breath odor, hair & nail changes, fatigue, irritability. Zn: Nausea, vomiting, abdominal pain/cramps, dyspepsia, GI discomfort/irritation, gastritis, diarrhea, metallic taste, loss of appetite, headache, drowsiness.