Sulfadimethoxine

Severe renal or hepatic failure; blood disorders; hypersensitivity to sulfonamides; acute porphyria; SLE. Pregnancy (3rd trimester) and lactation; infants ≤2 mth.

Renal or hepatic impairment; history of allergy or asthma; AIDS; G6PD deficiency; elderly; ensure adequate fluid intake to reduce risk of crystalluria. Discontinue use if rash occurs.

Nausea, vomiting, anorexia, diarrhoea; hypersensitivity reactions, SLE, serum sickness-like syndrome, liver necrosis and hepatomegaly, myocarditis, pulmonary eosinophilia and fibrosing alveolitis, vasculitis, hypoglycaemia, hypothyroidism, neurological reactions, jaundice and kernicterus in premature neonates. Pseudomembranous colitis.
Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, blood dyscrasias, anaphylaxis.

Potentiates effects of oral anticoagulants, methotrexate, phenytoin. Compounds that render urine acidic increase risk of crystalluria.

Interference with tests for urea, creatinine, urinary glucose, urobilinogen.

Description:
Mechanism of Action: Sulfadimethoxine is a long-acting sulfonamide which is used in veterinary medicine, sometimes in combination with baquiloprim or ormetoprim. It was formerly used in the treatment of UTI in humans.

Sulphonamides