Silgram Dosage & Drug Information

Concise Prescribing Info

Contents

Sultamicillin (ampicillin & sulbactam). Per tab Sultamicillin tosylate 750 mg. Per 375 mg vial Ampicillin 250 mg, sulbactam 125 mg. Per 750 mg vial Ampicillin 500 mg, sulbactam 250 mg. Per 1.5 g vial Ampicillin 1 g, sulbactam 500 mg

Indications/Uses

Tab: Treatment of infections where β-lactamase-producing organisms might occur including uncomplicated gonorrhea, otitis media, resp tract infections & UTI. Inj: Treatment of upper & lower resp tract & gynecological infections. Prophylaxis to reduce the risk of infections following surgery or caesarean section during birth.

Dosage/Direction for Use

Tab Adult 375-750 mg bid. Uncomplicated gonorrhea 2.25 g w/ probenecid 1 g. Inj Adult 1.5-3 g 6 hrly. Acute pelvic inflammatory disease 3 g 6 hrly in conjunction w/ doxycycline (100 mg 12 hrly by oral or IV). Parenteral regimen may be discontinued 24 hr after clinical improvement; oral doxycycline should be continued to complete the 14 days of therapy. Childn ≥1 yr 300 mg/kg daily by IV infusion in equally divided doses 6 hrly; ≥1 mth Mild to moderate infection 100-150 mg/kg daily in 4 divided doses.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to penicillins.

Special Precautions

Patients w/ mononucleosis. Overgrowth of nonsusceptible organisms & superinfections. Hepatic, renal & hematopoietic dysfunction. Pregnancy & lactation. Neonates & infants.

Adverse Reactions

Serious anaphylactoid reactions. Diarrhea or loose bowel, nausea, vomiting, epigastric distress & abdominal cramps; anemia, thrombocytopenia, eosinophilia & leukopenia; transient elevations of ALT (SGPT) & AST (SGOT) transaminases, bilirubinemia, abnormal hepatic function & jaundice; rash, itching & other skin reactions.

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Drug Interactions

Increased risk of bleeding w/ warfarin & MTX. May decrease efficacy of estrogen-containing OCs. Reduced excretion w/ probenecid. Allopurinol, aminoglycosides.

MIMS Class

Penicillins

ATC Classification

J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
J01CR01 - ampicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Silgram FC tab 750 mg

Packing/Price

100's (P1,210.44/box);30's

Form

Silgram 1.5 g inj

Packing/Price

1's (P739.76/vial)

Form

Silgram 375 mg inj

Packing/Price

1's (P280.56/vial)

Form

Silgram 750 mg inj

Packing/Price

1's (P450.24/vial)

Silgram

sultamicillin

ampicillin + sulbactam

Manufacturer:

Cathay Drug

Distributor:

Cathay Drug