Piptaz Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Per 2 g/250 mg Piperacillin Na 2 g, tazobactam Na 250 mg. Per 4 g/500 mg Piperacillin Na 4 g, tazobactam Na 500 mg

Indications/Uses

For documented multidrug resistant gm -ve infections due to organisms proven or suspected to be susceptible to Piperacillin/ Tazobactam except CNS infections; & for polymicrobial infections (eg, mixed aerobic & anaerobic infections in which other agents have insufficient activity or are contraindicated due to toxic potential).

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Dosage/Direction for Use

Administer by IV infusion over 30 min. Duration of therapy: 7-10 days. Adult Usual total daily dose: 3.375 g every 6 hr. Nosocomial pneumonia Duration of therapy: 7-14 days. All indication except nosocomial pneumonia Renal impairment CrCl >40 mL/min 3.375 g every 6 hr; 20-40 mL/min 2.25 g every 6 hr; <20 mL/min 2.25 g every 8 hr. Hemodialysis 2.25 g every 12 hr & administer 0.75 g following each hemodialysis session of hemodialysis days. CAPD 2.25 g every 12 hr. Nosocomial pneumonia Renal impairment CrCl >40 mL/min 4.5 g every 6 hr; 20-40 mL/min 3.375 g every 6 hr; <20 mL/min 2.25 g every 6 hr. Hemodialysis 2.25 g every 8 hr & administer 0.75 g following each hemodialysis session of hemodialysis days. CAPD 2.25 g every 8 hr. Community-acquired pneumonia, intraabdominal infections (appendicitis or peritonitis), uncomplicated skin & skin structure infection, pelvic inflammatory disease Ped weighing >40 kg 3.375 g every 6 hr + aminoglycoside or 4.5 g every 6 hr; ≥9 mth weighing up to 40 kg 100 mg/12.5 mg/kg every 8 hr; 2-9 mth 80 mg/10 mg/kg every 8 hr.

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Overdosage

View Piptaz overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity to penicillins, cephalosporins & β-lactamase antibiotics or inhibitors, & tetracyclines.

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Special Precautions

Cystic fibrosis, bowel inflammation, bleeding problems, CHF, or kidney problems. Patient on dialysis. History of severe diarrhea or bowel problems due to antibiotics. Salt-restricted diet or low blood K levels. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Agitation; constipation; diarrhea; dizziness; headache; indigestion; nausea; pain; swelling or redness at the inj site; sleeplessness; vomiting; severe allergic reactions (rash; hives; itching; difficulty of breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; chest pain; decreased urination; depression; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hallucination; inflammation at the inj site; prolonged muscle relaxation; red, swollen, or blistered skin; seizure; severe diarrhea, vomiting, or stomach pain; shortness of breath; swelling of the hands, ankles, or feet; tremor; unusual tiredness or weakness; vag irritation or discharge; vein inflammation or tenderness; yellowing of the eyes or skin.

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Drug Interactions

Decreased effectiveness w/ aminoglycosides (eg, tobramycin) or OCs. Decreased effectiveness of anticoagulants (eg, warfarin). Increased risk of side effects w/ chemotherapy or diuretics (eg, furosemide & hydrochlorothiazide); heparin, MTX, or non-depolarizing muscle relaxants (eg, vecuronium); probenecid. Decreased effectiveness w/ tetracyclines.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Piptaz detailed prescribing information

Storage

View Piptaz storage conditions for details to ensure optimal shelf-life.

Description

View Piptaz description for details of the chemical structure and excipients (inactive components).

Action

View Piptaz mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Penicillins

ATC Classification

J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Piptaz 2 g/250 mg powd for inj

Packing/Price

1's (P660.65/vial)

Form

Piptaz 4 g/500 mg powd for inj

Packing/Price

1's (P1,149.1/vial)

Piptaz

piperacillin + tazobactam

Manufacturer:

UNILAB, Inc

Distributor:

UNILAB, Inc