Forcad Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Warnings Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Simvastatin

Indications/Uses

Reduction of LDL-C, Apo B, & triglycerides, & increase HDL-C in the treatment of hyperlipidaemias including hypercholesterolaemias, combined (mixed) hyperlipidaemia (type IIa or IIb hyperlipoproteinaemias), hypertriglyceridemia (type IV) & primary dysbetalipoproteinaemia (type III); adjunct therapy in patients w/ HoFH who have some LDL-receptor function; CV risk reduction in patients w/ ASCVD or DM.

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Dosage/Direction for Use

Primary hypercholesterolaemia, combined hyperlipidaemia 10-20 mg daily at night, adjusted at intervals of at least 4 wk. Usual range: 10-80 mg once daily at night. HoFH 40 mg daily at night or 80 mg daily in 3 divided doses (largest dose at night). Prevention of CV events Initially 20-40 mg daily at night, adjusted at intervals of at least 4 wk; max: 80 mg once daily at night. Concomitant use w/ ciclosporin, fibrate or lipid-lowering dose of nicotinic acid Max: 10 mg daily, w/ amiodarone or verapamil Max: 20 mg daily, w/ diltiazem Max: 40 mg daily.

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Administration

May be taken with or without food.

Warnings

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Special Precautions

Not to be given to patients w/ acute liver disease or unexplained persistent raised serum-aminotransferase conc. Discontinue if marked increase in serum-aminotransferase or creatine phosphokinase conc occur. Avoid during pregnancy since there is a possibility to interfere w/ fetal sterol synthesis. 10 mg & 20 mg: Contains tartrazine which may cause allergic reaction (including bronchial asthma) in certain susceptible person.

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Adverse Reactions

GI disturbances. Headache, skin rashes, dizziness, blurred vision & dysgeusia. Reversible increases in serum-aminotransferase conc. Myopathy, characterized by myalgia & muscle weakness & associated w/ increase creatine phosphokinase conc, especially in patients taking immunosuppressive drugs, fibric acid derivatives or nicotinic acid. Rarely, rhabdomyolysis w/ acute renal failure.

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Drug Interactions

Increased risk of myopathy w/ ciclosporin, itraconazole, ketoconazole, erythromycin, clarithromycin, HIV-PIs, & nefazodone; fibric acid derivatives or nicotinic acid.

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Storage

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Description

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Action

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MIMS Class

Dyslipidaemic Agents

ATC Classification

C10AA01 - simvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.

Regulatory Classification

Presentation/Packing

Form

Forcad FC tab 10 mg

Packing/Price

30's

Form

Forcad FC tab 20 mg

Packing/Price

30's

Form

Forcad FC tab 40 mg

Packing/Price

30's

Forcad

simvastatin

Manufacturer:

Lloyd

Distributor:

Corbridge