Carbenoxolone: Uses, Dosage, Side Effects and More

This information is not country-specific. Please refer to the Philippines prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Gastro-oesophageal reflux disease

Adult: 20 mg tid.

Topical/Cutaneous
Mouth ulceration

Adult: Apply 2% gel 4 times daily.

What are the brands available for Carbenoxolone in Philippines?

Rowagel

Contraindications

Hypokalaemia; cardiac failure and in those receiving cardiac glycosides. Pregnancy, elderly, child <3 yrs.

Special Precautions

Cardiac disease, hypertension, impaired hepatic or renal function.

Adverse Reactions

Sodium and water retention, hypokalaemia.

Drug Interactions

Antagonism with amiloride and spironolactone. Exacerbates hypokalaemia associated with diuretics.
Potentially Fatal: Risk of toxicity with digitalis glycosides.

Action

Description:
Mechanism of Action: Carbenoxolone is a synthetic derivative of glycyrrhizinic acid (a constituent of liquorice). It acts by protecting the mucosal barrier from acid-pepsin attack and increasing mucosal mucin production.
Pharmacokinetics:
Absorption: Absobed in the GI tract, mainly from the stomach.
Distribution: Highly bound to plasma proteins.
Excretion: Mainly excreted in the faeces via the bile.

MIMS Class

Antacids, Antireflux Agents & Antiulcerants / Preparations for Oral Ulceration & Inflammation

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