Aubrex Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Celecoxib

Indications/Uses

Treatment of RA & OA. Adjunctive treatment of adenomatous colorectal polyps. Management of acute pain & dysmenorrhea.

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Dosage/Direction for Use

OA 200 mg daily as a single dose or in 2 divided doses. RA 100-200 mg bid. Pain & dysmenorrhea Initially 400 mg followed by an additional 200 mg, if necessary, on the 1st day. 200 mg bid is given thereafter. Adenomatous colorectal polyps 400 mg bid.

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Overdosage

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Administration

May be taken with or without food: Dose for OA/RA may be given w/ or w/o meals, but doses for adenomatous colorectal polyps must be given w/ meals.

Contraindications

History of hypersensitivity to sulfonamides or allergy to NSAIDs. Asthma, severe heart failure, inflammatory bowel disease, renal impairment associated w/ CrCl <30 mL/min. History of stroke (CVA), heart attack (MI), CABG, uncontrolled HTN, CHF NYHA II-IV.

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Special Precautions

Patients w/ ischemic heart disease, risk factors for heart disease, HTN, hyperlipidemia, diabetes, smoking, peripheral arterial disease. Use the lowest effective dose for the shortest duration of treatment considering the CV risk. Discontinue treatment in case of appearance of skin rash & signs of hypersensitivity. Potential for GI & renal toxicities. Avoid use during 3rd trimester of pregnancy. May adversely affect pregnancy & may cause uterine inertia & premature closure of ductus arteriosus. Increased risk of spontaneous abortion after use of prostaglandin synthesis inhibitors in early pregnancy. Potential for adverse reactions in nursing infants; discontinue nursing or the drug taking into account the expected benefit of the drug to the mother.

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Use In Pregnancy & Lactation

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Adverse Reactions

GI disturbances eg, GI discomfort, nausea & diarrhea.

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Drug Interactions

Changes in plasma conc w/ CYP2C9 inhibitors or substrates. Increased plasma conc w/ fluconazole. Individuals w/ reduced CYP2D6 activity may exhibit potential CYP2D6-associated drug-drug interactions.

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Storage

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Description

View Aubrex description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

ATC Classification

M01AH01 - celecoxib ; Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, coxibs.

Regulatory Classification

Presentation/Packing

Form

Aubrex cap 200 mg

Packing/Price

50's (P26/cap)

Aubrex

celecoxib

Manufacturer:

Lloyd

Distributor:

Corbridge