Ambesyl Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Amlodipine besilate

Indications/Uses

HTN, chronic stable angina pectoris & vasospastic (Prinzmetal's) angina.

Click to view Ambesyl detailed prescribing information

Dosage/Direction for Use

Adult HTN, angina Initially 5 mg once daily. Max daily dose: 10 mg. Childn & adolescent 6-17 yr HTN Initially 2.5 mg once daily, up-titrated to 5 mg once daily if BP goal is not achieved after 4 wk.

Click to view Ambesyl detailed prescribing information

Overdosage

View Ambesyl overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to amlodipine & dihydropyridines. Severe hypotension, shock (including cardiogenic shock), obstruction of the outflow tract of the left ventricle (eg, high grade aortic stenosis), haemodynamically unstable heart failure after acute MI.

Click to view Ambesyl detailed prescribing information

Special Precautions

Hypertensive crisis. Patients w/ heart failure & CHF. Hepatic & renal impairment. Minor or moderate influence on the ability to drive & use machines. Pregnancy & lactation. Childn <6 yr. Elderly.

Click to view Ambesyl detailed prescribing information

Use In Pregnancy & Lactation

Click to view Ambesyl detailed prescribing information

Adverse Reactions

Oedema. Somnolence, dizziness, headache (especially at beginning of treatment); visual disturbance (including diplopia); palpitations; flushing; dyspnoea; abdominal pain, nausea, dyspepsia, altered bowel habits (including diarrhoea & constipation); ankle swelling, muscle cramps; fatigue, asthenia.

Click to view Ambesyl detailed prescribing information

Drug Interactions

Increased exposure & risk of hypotension w/ strong or moderate CYP3A4 inhibitors (PIs, azole antifungals, macrolides eg, erythromycin or clarithromycin, verapamil or diltiazem). Lower plasma conc w/ strong CYP3A4 inducers (eg, rifampicin, Hypericum perforatum). Increased BP lowering effects w/ grapefruit or grapefruit juice & medicinal products w/ antihypertensive properties. Risk of hyperkalemia w/ dantrolene infusion. Increase tacrolimus blood levels. May increase exposure of mTOR inhibitors (eg, sirolimus, temsirolimus & everolimus). Increase trough conc of ciclosporin in renal transplant patients. Increased exposure w/ simvastatin.

Click to view Ambesyl detailed prescribing information

Storage

View Ambesyl storage conditions for details to ensure optimal shelf-life.

Description

View Ambesyl description for details of the chemical structure and excipients (inactive components).

Action

View Ambesyl mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Calcium Antagonists / Anti-Anginal Drugs

ATC Classification

C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Ambesyl tab 10 mg

Packing/Price

100's;30's (P401.25/pack)

Form

Ambesyl tab 5 mg

Packing/Price

100's;30's (P215.25/pack)

Ambesyl

amlodipine

Manufacturer:

Sandoz

Distributor:

Sandoz