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GLP-1RAs outperform DPP-4is in preventing hyperkalemia, RASi therapy discontinuation
Individuals with type 2 diabetes (T2D) treated in routine clinical care appear to fare better with glucagon-like peptide-1 receptor agonists (GLP-1RAs) than with dipeptidyl peptidase-4 inhibitors (DPP-4is), with GLP-1Ras being associated with lower rates of hyperkalemia and renin-angiotensin system inhibitor (RASi) medication discontinuation, as shown in an observational study.

Multiple factors influence risks of cirrhosis, HCC in veterans with MAFLD
The incidence of cirrhosis and hepatocellular carcinoma (HCC) among veterans differs according to demographic and clinical characteristics, with the lowest rate seen among Asians, reports a study.

Nephrolithiasis patients at higher risk of cardiovascular events
Individuals with nephrolithiasis show a higher carotid-femoral pulse wave velocity (CF-PWV) at baseline and a greater increase in CF-PWV changes within 10 years than those without, reports a study, noting an elevated cardiovascular risk for nephrolithiasis patients.

Urinary peptides linked to hypertension
Several urinary peptides show a significant association with hypertension, with apparent “differential regulation of collagen-derived peptides,” a recent study has shown. In addition, peptides associated with vascular calcification and sodium regulation are also involved.




