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Unique interventional pulmonology book highlights diagnostic, therapeutic case studies
Dr Jamalul Azizi Abdul Rahaman, a consultant pulmonologist (respiratory physician) at Sultan Idris Shah Serdang Hospital, and Dr Tinku Joseph, chief of Interventional Pulmonology at Amrita Institute of Medical Sciences in India, edited a book titled “A Case-Based Approach to Interventional Pulmonology: A Focus on Asian Perspectives.” The book was launched in conjunction with the 9th Asian Pacific Congress on Bronchology and Interventional Pulmonology, held at Le Meridien Hotel, Putrajaya, in May 2023. Here, they provide a summary of the book and answer questions posed by MIMS Doctor.
Durvalumab plus radiotherapy shows promise in unresectable NSCLC
In the treatment of patients with programmed cell death ligand 1 (PD-L1)-positive, unresectable, and locally advanced nonsmall cell lung cancer (NSCLC), the use of durvalumab immunotherapy in combination with curative radiotherapy yields survival gains with tolerable adverse events (AEs), as shown in the results of the phase II DOLPHIN trial.
Stage IIIA/B NSCLC: Perioperative nivolumab plus chemo improves pCR, survival vs neoadjuvant chemo
Perioperative nivolumab plus platinum-based chemotherapy improves pathological complete response (pCR) rate and survival outcomes vs neoadjuvant platinum-based chemotherapy alone in patients with resectable stage IIIA/B non-small-cell lung cancer (NSCLC), results of the NADIM II trial have shown.
SMAD7 overexpression boosts EGFR-CAR-T function against NSCLC
Epidermal growth factor receptor (EGFR)-mothers against decapentaplegic homologue 7 (SMAD7)-Chimeric antigen receptor (CAR) T-cell therapy against nonsmall-cell lung cancer (NSCLC) is on a par with EGFR-dominant‒negative transforming growth factor (TGFbeta) receptor 2 (DNR)-CAR-T in terms of efficacy and resistance to negative TGFβ regulation, a study has shown.
