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More evidence supports enzalutamide’s link with poorer mood and cognitive outcomes in mCRPC
Patients with metastatic castration-resistant prostate cancer (mCRPC) treated with enzalutamide reported more fatigue, depression and deterioration in perceived cognitive ability, and slower reaction time than those receiving abiraterone acetate, according to results of the ACE study.
Abdominal fat tied to reduced brain function in middle-aged men at high dementia risk
Higher abdominal fat, particularly around the pancreas, appears to contribute to lower cognition and brain volumes among middle-aged men at high risk of Alzheimer’s dementia, reports a study. This suggests a possible sex-specific link between distinct abdominal fat and brain health.
Detecting Alzheimer’s disease biomarkers: Timing matters
A 20-year nested case–control study in China has shown sequential and temporal changes in biomarkers 6–18 years before diagnosis of Alzheimer’s disease (AD). Accelerated changes in cerebrospinal fluid (CSF) biomarkers were found after the onset of cognitive impairment, followed by plateaus at AD diagnosis.
Thrombectomy tied to better functional outcomes in large ischaemic stroke patients
Endovascular thrombectomy (EVT) in addition to medical care results in significantly improved functional outcomes at 1 year in acute ischaemic stroke patients with a large core infarct compared with medical care alone, as shown in the SELECT2 study. This benefit persists across ischaemic core strata on imaging.
Long-term lecanemab reduces cognitive decline in early AD
Treatment with lecanemab continue to provide benefits to patients with early Alzheimer’s disease (AD) through 24 months, according to the results of the ongoing open-label extension study of Clarity AD. Those who have been treated much later also show disease improvements.